Online Inquiry
STOCK Mc4rtm3.1(cre)Lowl/J
Cat. No.: CEMM-07250825
Common Name: Mc4r-2a-Cre
Mc4r-2a-Cre knock-in mice may be useful for studying appetite control and obesity.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Mc4rtm3.1(cre)Lowl
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| Allele Name |
targeted mutation 3.1
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| Allele Attributes |
Recombinase-expressing
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| Gene Symbol |
Mc4r
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| Gene Name |
melanocortin 4 receptor
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| Chromosome |
18
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| Expressed Genes |
Cre, Cre recombinase, bacteriophage P1
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| MGI Accession ID | show more close |
| Site of Expression |
Cre is expressed across the rostral-caudal extent of the neuraxis, including robust expression in the paraventricular nucleus of the hypothalamus, lateral hypothalamus, and anterior bed nucleus of the stria terminalis.
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| Strain of Origin |
129S6/SvEvTac
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| Molecular Note |
A t2a cleaving peptide from Thosea asigna virus and a Cre recombinase gene were inserted downstream of the stop codon.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
B6129SF2/J
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| Breeding Considerations |
When maintaining a live colony, heterozygous mice may be bred together. Female homozygotes display fertility issues.
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| Breeding Strategy |
Heterozygote x Homozygote
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For Research Use Only.
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