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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| BALB/c-Gt(ROSA)26Sortm1(CAG-EGFP, -BphP1/mCherry/TetR)Vvv/J (Cat. No.: CEMM-07251042) | Inquiry | |
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These loxP-BphP1 mice are a Cre-dependent, Tet-controllable optogenetic line, created by targeted insertion of a CAG promoter, loxP-flanked EGFP-polyA cassette and the photoreceptor/fluorescent/tet-repressor fusion protein (RpBphP1/mCherry/TetR) into the the Gt(ROSA)26Sor locus. Widespread EGFP expression is replaced by RpBphP1/mCherry/TetR fusion protein expression upon Cre recombinase exposure. Further introduction of a BphP1 binding partner::nuclear-localization tag::VP16 activation domain construct and a tetO (TRE) promoter-driven reporter gene allow the subsequent control of reporter gene expression via illumination with near-infrared (NIR) light (~740-780 nm) as well as tetracycline/doxycycline.
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| B6;129S6-Prkcgtm2(cre/ERT2)Ddg/J (Cat. No.: CEMM-07250789) | Inquiry | |
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These knock-in/knock-out targeted mutant mice express tamoxifen-inducible cre-ERT2 fusion protein from the mouse Prkcg promoter in the spinal cord dorsal horn, hippocampus, cerebellum, and corticospinal tract.
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| B6N.Cg-Syt2tm2.1Sud/J (Cat. No.: CEMM-07250844) | Inquiry | |
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Exon 2 of the mouse Syt2 gene is flanked by loxP1 sites in this Syt2 cKO strain. Cre-mediated excision of the floxed region is believed to result in a knock-out allele.
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| STOCK Tcerg1ltm1.1(cre/ERT2)Zjh/J (Cat. No.: CEMM-07250969) | Inquiry | |
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Tcerg1l-2A-CreER knock-in mice express tamoxifen-inducible CreERT2 fusion protein from the mouse Tcerg1l (transcription elongation regulator 1-like) promoter in TCERG1L-positive neurons of the neocortex, hypothalamus and tectum.
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| STOCK Adcyap1tm1.1(cre/ERT2)Zjh/J (Cat. No.: CEMM-07250968) | Inquiry | |
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Adcyap1-2A-CreER knock-in mice express tamoxifen-inducible CreERT2 fusion protein from the mouse Adcyap1 (adenylate cyclase activating polypeptide 1) promoter in ADCYAP1-positive neurons of the neocortex and pons.
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| B6;129S-Gt(ROSA)26Sortm39(CAG-hop/EYFP)Hze/J (Cat. No.: CEMM-07250291) | Inquiry | |
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These Ai39 mice conditionally express an improved Halorhodopsin/EYFP fusion protein from the endogenous Gt(ROSA)26Sor locus. Following Cre-mediated removal of the STOP cassette, EYFP expression is observed in the cre-expressing cells. Subsequent illumination of these cells with yellow-to-red light leads to reversible photoinhibition of action potential firing/neural activity in these cells. These Ai39 mice are useful for optogenetic studies to express an inhibitory opsin that effectively silences the activity of cortical neurons.
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| B6;129S-Nlgn2tm1.1Gchn/J (Cat. No.: CEMM-07250894) | Inquiry | |
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An Arg215His (R215H) loss-of-function point mutation in the human neuroligin 2 gene has been identified in schizophrenia patients. These NL2 R215H mice carry a corresponding R215H point mutation in the mouse Nlgn2 gene in addition to loxP sites flanking exons 4-7.
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| B6.Cg-Gt(ROSA)26Sortm1(CAG-BST2, -EGFP)Bsz/J (Cat. No.: CEMM-07250766) | Inquiry | |
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Cre-mediated excision of a floxed Stop cassette enables directed expression of the human tetherin (BST2) cDNA and an EGFP reporter useful in studies of viral infection.
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| B6.Cg-Shank3tm1.2Bux/J (Cat. No.: CEMM-07250370) | Inquiry | |
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The Shank3Δ ex4-9 allele has a deletion of the ankyrin repeat domains (exons 4-9) of the Shank3 gene; this deletion prevents full-length Shank3 expression. As Shank3 is necessary for forming functional glutamatergic synapses between receptors and cytoskeletal/scaffolding elements, these mice may be useful for studying synaptic glutamate receptor development/function, transmission and plasticity, as well as Shank3 haploinsufficiency, neurobehavioral manifestations of 22q13 deletion syndrome and/or autism spectrum disorders.
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| C57BL/6N-Gt(ROSA)26Sortm1(CAG-GCaMP6f)Khakh/J (Cat. No.: CEMM-07250743) | Inquiry | |
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The Lck-GCaMP6fflox (or R26-Lck-GCaMP6fflox) knock-in mice have Cre-dependent expression of a plasma membrane-targeted GCaMP6f. Lck-GCaMP6f is a detector of single neuronal action potentials with fast response kinetics. It has an Lck-tag to improve its ability to reveal calcium signals in near membrane regions and fine processes (e.g., astrocyte processes). After Cre exposure, bright GCaMP6f fluorescence is observed following calcium binding (such as neuronal activation).
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For Research Use Only.