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STOCK Adcyap1tm1.1(cre/ERT2)Zjh/J
Cat. No.: CEMM-07250968
Common Name: Adcyap1-2A-CreER
Adcyap1-2A-CreER knock-in mice express tamoxifen-inducible CreERT2 fusion protein from the mouse Adcyap1 (adenylate cyclase activating polypeptide 1) promoter in ADCYAP1-positive neurons of the neocortex and pons.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Adcyap1tm1.1(cre/ERT2)Zjh
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Recombinase-expressing; Inducible
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| Gene Symbol |
Adcyap1
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| Gene Name |
adenylate cyclase activating polypeptide 1
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| Chromosome |
17
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| MGI Accession ID | show more close |
| Strain of Origin |
(C57BL/6 x 129S4/SvJae)F1
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| Molecular Note |
A targeting vector was designed to insert an internal ribosome entry site (IRES) fused to a CreER fusion gene followed by a FRT flanked neo cassette upstream of the stop codon of the adenylate cyclase activating polypeptide 1 (Adcyap1) gene. CreER incorporates Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain. The neomycin cassette was excised with Flp recombinase.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
Heterozygous and homozygous mice are viable and fertile.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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