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B6;129S-Nlgn2tm1.1Gchn/J
Cat. No.: CEMM-07250894
Common Name: NL2 R215H
An Arg215His (R215H) loss-of-function point mutation in the human neuroligin 2 gene has been identified in schizophrenia patients. These NL2 R215H mice carry a corresponding R215H point mutation in the mouse Nlgn2 gene in addition to loxP sites flanking exons 4-7.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Nlgn2tm1.1Gchn
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); Humanized sequence
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| Gene Symbol |
Nlgn2
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| Gene Name |
neuroligin 2
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| Chromosome |
11
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| MGI Accession ID | show more close |
| Strain of Origin |
(129S/SvEv x C57BL/6J)F1
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| Molecular Note |
A loxP site and an FRT flanked PGK-neomycin cassette (in reverse transcriptional orientation) are placed in intron 3 along with a loxP site in intron 7 (thus flanking exons 4-7 with loxP sites). In addition, an Arg215His (R215H amino acid; G644A nucleotide) mutation is introduced to exon 4 of the gene. Flp-mediated recombination removed the FRT flanked neo cassette. The Arg215His (R215H) loss-of-function point mutation in the human gene has been identified in schizophrenia patients.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
B6129SF2/J
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| Breeding Considerations |
Heterozygous and homozygous mice retaining the floxed exons are viable an fertile.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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