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B6.Cg-Gt(ROSA)26Sortm1(CAG-BST2, -EGFP)Bsz/J
Cat. No.: CEMM-07250766
Common Name: hBST2
Cre-mediated excision of a floxed Stop cassette enables directed expression of the human tetherin (BST2) cDNA and an EGFP reporter useful in studies of viral infection.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Gt(ROSA)26Sortm1(CAG-BST2,-EGFP)Bsz
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); Reporter; Inserted expressed sequence; Humanized sequence
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| Gene Symbol |
Gt(ROSA)26Sor
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| Gene Name |
gene trap ROSA 26
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| Chromosome |
6
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| Expressed Genes |
BST2, bone marrow stromal cell antigen 2, human
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| MGI Accession ID | show more close |
| Site of Expression |
When these mutant mice are bred to mice that express Cre recombinase, the resulting offspring will express human tetherin in the Cre-expressing tissues.
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| Strain of Origin |
B6(Cg)-Tyrc-2J
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| Molecular Note |
The targeting construct is designed from 5' to 3' as follows: CAG-loxP-neomycin (in reverse transcriptional orientation)-Stop-loxP-human BST2/tetherin cDNA-FRT IRES-EGFP-FRT polyA and was introduced to intron 1 of the mouse Gt(ROSA)26Sor locus.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
Heterozygous and homozyous floxed mice are viable and fertile.
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For Research Use Only.
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