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B6N.Cg-Syt2tm2.1Sud/J
Cat. No.: CEMM-07250844
Common Name: Syt2 cKO
Exon 2 of the mouse Syt2 gene is flanked by loxP1 sites in this Syt2 cKO strain. Cre-mediated excision of the floxed region is believed to result in a knock-out allele.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Syt2tm2.1Sud
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| Allele Name |
targeted mutation 2.1
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| Allele Attributes |
Conditional ready (e.g. floxed)
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| Gene Symbol |
Syt2
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| Gene Name |
synaptotagmin II
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| Chromosome |
1
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| MGI Accession ID | show more close |
| Strain of Origin |
(129S6/SvEvTac x C57BL/6J)F1
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| Molecular Note |
The targeting construct includes a loxP site inserted into intron 1 and the following inserted into intron 2: loxP2 - inverted FRT1 - loxP1 - FRT2 - inverted neomycin casstte - inverted FRT1 - inverted Syt9 coding sequence - inverted loxP1 - inverted loxP2 - FRT2. The Syt9 cDNA incorporated in the allele (intended to function as a conditional knock-in) is non-functional. Flp-mediated recombination excised the region between the two FRT2 sites, leaving a loxP1 site in intron 1 and the following in intron 2: loxP5171-inverted FRT1-loxP1-FRT2.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6NJ
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| Breeding Considerations |
Heterozygous and homozygous mice are viable and fertile.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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