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B6.Cg-Shank3tm1.2Bux/J
Cat. No.: CEMM-07250370
Common Name: Shank3- (Shank3Δ ex4-9)
The Shank3Δ ex4-9 allele has a deletion of the ankyrin repeat domains (exons 4-9) of the Shank3 gene; this deletion prevents full-length Shank3 expression. As Shank3 is necessary for forming functional glutamatergic synapses between receptors and cytoskeletal/scaffolding elements, these mice may be useful for studying synaptic glutamate receptor development/function, transmission and plasticity, as well as Shank3 haploinsufficiency, neurobehavioral manifestations of 22q13 deletion syndrome and/or autism spectrum disorders.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Shank3tm1.2Bux
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| Allele Name |
targeted mutation 1.2
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| Allele Attributes |
Null/Knockout
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| Gene Symbol |
Shank3
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| Gene Name |
SH3 and multiple ankyrin repeat domains 3
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| Chromosome |
15
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| MGI Accession ID | show more close |
| Strain of Origin |
B6.Cg-Thy1a
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| Molecular Note |
A loxP site was inserted upstream of exon 4 and an FRT flanked neo cassette and second loxP site were inserted downstream of exon 9 via homologous recombination. Flp mediated recombination removed the neo cassette. Cre mediated recombination removed exons 4 - 9. Quantitative PCR and immunoblot analysis confirmed the absence of mRNA and protein expression in homozygous mice.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
Heterozygous males display less social sniffing and emit fewer ultrasonic vocalizations during interactions with estrus female mice. Therefore when maintaining a live colony, heterozygous females may be bred with wildtype males from the colony or with C57BL/6J inbred males.
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For Research Use Only.
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