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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6.Cg-Pex1tm1.1Sjms/Mmjax (Cat. No.: CEMM-07250553) | Inquiry | |
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These Pex1-G844D mice exhibit phenotypes consistent with several features of the mild form of Zellweger spectrum disorder (ZSD) including: growth retardation, shortened life expectancy, fatty livers with cholestasis and retinopathy. In addition, this Pex1 allele possesses loxP sites for the creation of conditional knock out animals.
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| STOCK Mir301tm1Mtm/Mmjax (Cat. No.: CEMM-07250259) | Inquiry | |
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These microRNA 301 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. LacZ expression is widespread. This mutant mouse strain may be useful in studies of microRNA biology.
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| STOCK Insm1tm1.1Mgn/Mmjax (Cat. No.: CEMM-07250519) | Inquiry | |
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Insm1(GFP-Cre) mice contain a GFP/Cre fusion cassette that replaces the entire coding region of the Insm1 (insulinoma-associated 1) gene. Mice homozygous for mutation are not viable. This strain may be useful for lineage tracing of Insm1+ cells and for studying pancreatic endocrine, neural and olfactory epithelium progenitor cells.
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| B6(Cg)-Scn1atm1.1Dsf/J (Cat. No.: CEMM-07250588) | Inquiry | |
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These conditional Scn1a-A1783V mice express the Dravet Syndrome/SMEI-associated mutation A1783V in the presence of Cre recombinase, and exhibit Dravet-like phenotypes including spontaneous seizures.Of note, this strain is "open access", and available to for-profit organizations.
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| STOCK Mir205tm1Mtm/Mmjax (Cat. No.: CEMM-07250257) | Inquiry | |
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These microRNA 205 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. LacZ expression is observed in pharyngeal arches and limbs at E11.5 and thymus, skin and kidney at E18.5. This mutant mouse strain may be useful in studies of microRNA biology.
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| B6;129-Myrftm1Barr/J (Cat. No.: CEMM-07250185) | Inquiry | |
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Myrftm1Barr mice harbor loxP sites flanking exon 8 of the myelin regulatory factor gene. When bred to mice that express Cre recombinase, the resulting offspring will have this region deleted in the cre-expressing tissue(s). These mice may be useful in generating conditional mutations for studying the role of Myrf in CNS myelination and other cellular processes.
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| 129S-Gt(ROSA)26Sortm1(NOTCH3)Sat/Mmjax (Cat. No.: CEMM-07250268) | Inquiry | |
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In this ROSA NOTCH3-WT76 knock-in strain, expression of the human NOTCH3 is blocked by an upstream loxP-flanked STOP sequence. Cre-mediated excision results in expression of human NOTCH3 and GFP targeted to the nucleus. Expression of NOTCH3 in vascular smooth muscle cells rescues the stroke susceptibility phenotype of Notch3 knockout mice.
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| B6;129P-Fat3tm1.1Good/J (Cat. No.: CEMM-07250367) | Inquiry | |
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These FAT3 mutant mice possess loxP sites flanking exon 23 (transmembrane domain) of the FAT tumor suppressor homolog 3 gene, and may be useful for studying dendrite development.
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| B6;129S2-Rapgef3tm1Geno/J (Cat. No.: CEMM-07250399) | Inquiry | |
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This strain may be useful for generating conditional mutants for applications related to cognition and social dysfunction. Inserted loxP sites flank exons 3 to 6 of the Rapgef3 (Rap guanine nucleotide exchange factor 3) gene, an intracellular receptor for cyclic AMP.
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| B6.129-Slc12a6tm1Garo/J (Cat. No.: CEMM-07250413) | Inquiry | |
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This strain may be useful for generating conditional mutants for applications related to the neurodevelopmental and neurodegenerative disorder called hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum (HMSN/ACC). These mice possess loxP sites flanking exon 18 of the Slc12a6 gene, a K+/Cl- cotransporter associated with HMSN/ACC.
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For Research Use Only.