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B6.129-Slc12a6tm1Garo/J

Cat. No.: CEMM-07250413

This strain may be useful for generating conditional mutants for applications related to the neurodevelopmental and neurodegenerative disorder called hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum (HMSN/ACC). These mice possess loxP sites flanking exon 18 of the Slc12a6 gene, a K+/Cl- cotransporter associated with HMSN/ACC.
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Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Slc12a6tm1Garo
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Allele Name
targeted mutation 1
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Allele Attributes
Conditional ready (e.g. floxed); No functional change
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Gene Symbol
Slc12a6
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Gene Name
solute carrier family 12
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Chromosome
2
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MGI Accession ID
5318538
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Strain of Origin
129
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Molecular Note
An FRT and LoxP flanked neo cassette was inserted upstream of exon 18 and a loxP site was inserted downstream of exon 18 via homologous recombination.
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HUSBANDRY
Suggested Controls
C57BL/6J C57BL/6NJ
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Breeding Considerations
While maintaining a live colony, these mice are bred as homozygotes.
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For Research Use Only.
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