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B6.Cg-Pex1tm1.1Sjms/Mmjax
Cat. No.: CEMM-07250553
These Pex1-G844D mice exhibit phenotypes consistent with several features of the mild form of Zellweger spectrum disorder (ZSD) including: growth retardation, shortened life expectancy, fatty livers with cholestasis and retinopathy. In addition, this Pex1 allele possesses loxP sites for the creation of conditional knock out animals.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Pex1tm1.1Sjms
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); Humanized sequence
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| Gene Symbol |
Pex1
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| Gene Name |
peroxisomal biogenesis factor 1
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| Chromosome |
5
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| MGI Accession ID | show more close |
| Strain of Origin |
129 x C57BL/6
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| Molecular Note |
A targeting vector was designed to insert a loxP site into intron 11, a loxP-FRT flanked neomycin cassette into intron 13 and a G844D point mutation into exon 15. The mutation results in a G to A change at nucleotide 2531 altering the corresponding amino acid from glycine to aspartic acid at position 844. FLP-mediated recombination removed the FRT flanked neo cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
While maintaining a live colony, these mice are bred as heterozygotes. Mice homozygous for the mutation are growth retarded; approximately 50% of mice will not survive to a year. The Donating Investigator indicates that due to their small size, homozygotes require access to gel nutrition from weaning until 12 weeks of age.
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For Research Use Only.
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