Online Inquiry
B6;129-Myrftm1Barr/J
Cat. No.: CEMM-07250185
Common Name: MRF floxed
Myrftm1Barr mice harbor loxP sites flanking exon 8 of the myelin regulatory factor gene. When bred to mice that express Cre recombinase, the resulting offspring will have this region deleted in the cre-expressing tissue(s). These mice may be useful in generating conditional mutations for studying the role of Myrf in CNS myelination and other cellular processes.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Myrftm1Barr
show more
close
|
| Allele Name |
targeted mutation 1
show more
close
|
| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
show more
close
|
| Gene Symbol |
Myrf
show more
close
|
| Gene Name |
myelin regulatory factor
show more
close
|
| Chromosome |
19
show more
close
|
| MGI Accession ID | show more close |
| Strain of Origin |
129P2/OlaHsd
show more
close
|
| Molecular Note |
A targeting vector was used to flank exon 8 of the endogenous gene with loxP sites. The vector also contained an FRT flanked neomycin resistance cassette. Correctly targeted ES cells were injected into recipient blastocysts. The resulting chimeric animals were crossed to C57BL/6 mice. Heterozygous mice were crossed to the FlpER (129S4/SvJaeSor-Gt(ROSA)26Sortm1(FLP1)Dym) strain to remove the neo cassette, leaving a single FRT site upstream of exon 8 and the flanking loxP sites.
show more
close
|
| HUSBANDRY | |
|---|---|
| Suggested Controls |
B6129PF2/J
show more
close
|
| Breeding Considerations |
While maintaining a live colony, these mice are bred as homozygotes.
show more
close
|
For Research Use Only.
Related Products