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B6(Cg)-Scn1atm1.1Dsf/J
Cat. No.: CEMM-07250588
Common Name: floxed STOP Scn1a*A1783V
These conditional Scn1a-A1783V mice express the Dravet Syndrome/SMEI-associated mutation A1783V in the presence of Cre recombinase, and exhibit Dravet-like phenotypes including spontaneous seizures.Of note, this strain is "open access", and available to for-profit organizations.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Scn1atm1.1Dsf
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); Humanized sequence; No functional change
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| Gene Symbol |
Scn1a
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| Gene Name |
sodium channel
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| Chromosome |
2
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6J
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| Molecular Note |
A mini-gene cassette containing a loxP site, coding sequence for wild-type exon 26, bpA, an FRT flanked neomycin cassette, and a second loxP site was introduced into intron 25 and a A1783V mutation was introduced into exon 26. The mutation results in a C to T change at nucleotide 5348 altering the corresponding amino acid from alanine to valine at position 1783.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J Wild-type from the colony
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| Breeding Considerations |
While maintaining a live colony, these mice are bred as heterozygotes. The donating investigator has not attempted to generate homozygous mice to date.
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| Breeding Strategy |
Wild-type x Heterozygote; C57BL/6J x Heterozygote; Heterozygote x C57BL/6J; Heterozygote x Wild-type
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For Research Use Only.
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