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STOCK Mir205tm1Mtm/Mmjax
Cat. No.: CEMM-07250257
These microRNA 205 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. LacZ expression is observed in pharyngeal arches and limbs at E11.5 and thymus, skin and kidney at E18.5. This mutant mouse strain may be useful in studies of microRNA biology.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Mir205tm1Mtm
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); Reporter; Null/Knockout
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| Gene Symbol |
Mir205
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| Gene Name |
microRNA 205
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| Chromosome |
1
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| Expressed Genes |
lacZ, beta-galactosidase, E. coli
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| MGI Accession ID | show more close |
| Site of Expression |
LacZ expression is observed in pharyngeal arches and limbs at E11.5 and thymus, skin and kidney at E18.5.
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| Strain of Origin |
129P2/OlaHsd
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| Molecular Note |
A targeting vector was designed to insert an FRT site followed by a lacZ gene, a loxP site, a neomycin cassette, an FRT site and a loxP site (FRT lacZ-loxP-Neo-FRT loxP) upstream of the microRNA stem loop and one loxP site immediately downstream of the microRNA stem loop.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
While maintaining a live colony, these mice are bred as heterozygotes. The Donating Investigator has not developed a homozygous colony.
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For Research Use Only.
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