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129S-Gt(ROSA)26Sortm1(NOTCH3)Sat/Mmjax
Cat. No.: CEMM-07250268
In this ROSA NOTCH3-WT76 knock-in strain, expression of the human NOTCH3 is blocked by an upstream loxP-flanked STOP sequence. Cre-mediated excision results in expression of human NOTCH3 and GFP targeted to the nucleus. Expression of NOTCH3 in vascular smooth muscle cells rescues the stroke susceptibility phenotype of Notch3 knockout mice.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Gt(ROSA)26Sortm1(NOTCH3)Sat
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); Reporter; Inserted expressed sequence; Humanized sequence
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| Gene Symbol |
Gt(ROSA)26Sor
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| Gene Name |
gene trap ROSA 26
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| Chromosome |
6
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| Expressed Genes |
NOTCH3, notch 3, human
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| MGI Accession ID | show more close |
| Site of Expression |
EGFP and human NOTCH3 will be expressed in cells where promoters driving Cre recombinase are expressed.
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| Strain of Origin |
129S6/SvEvTac
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| Molecular Note |
A targeting vector containing a splice acceptor site, a loxP-flanked PGK neomycin cassette, a human NOTCH3 cDNA and an IRES-nuclear GFP sequence was inserted into the GT(ROSA)26Sor locus.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
While maintaining a live colony, these mice are bred as homozygotes.
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For Research Use Only.
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