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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| STOCK Tg(CAG-RFP*, -Dscam, -EGFP)1Pfu/J (Cat. No.: CEMM-07250565) | Inquiry | |
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DscamfloxGOF is a dual fluorescent Cre reporter and conditional Dscam gain-of-function model; expressing red fluorescence in widespread cells/tissues prior to Cre recombinase exposure, with Down syndrome cell adhesion molecule overexpression and green fluorescence in Cre recombinase expressing cells. These mice may be useful for studying developmental neurobiology, central nervous system patterning and retinal organization. In addition, these mice allow one to test the similarities between Down syndrome and the reduced neuronal cell numbers and novel circuitry/neurite targeting defects associated with Dscam overexpression/mis-expression.
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| STOCK Tg(Neurog1-cre)1Jejo/J (Cat. No.: CEMM-07250245) | Inquiry | |
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These Neurog1457-Cre may be useful for generating conditional mutations in Neurog1 lineages in the central and peripheral nervous systems.
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| B6;FVB-Ifi208Tg(Cspg4-cre)1Akik/J (Cat. No.: CEMM-07250117) | Inquiry | |
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These transgenic mice express the Cre recombinase under the control of the mouse chondroitin sulfate proteoglycan 4 (Cspg4) promoter/enhancer. Cre recombinase expression is detected in Cspg4 expressing glial cells and vasculature throughout the brain as well as in Cspg4-expressing cells in other tissues from late embryonic stages (~embryonic day 14) throughout adulthood. These transgenic mice may be may be crossed to various floxed mutants to delete floxed sequences specifically in Cspg4-expressing cells.
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| STOCK Tg(Pcp2-cre)1Amc/J (Cat. No.: CEMM-07250044) | Inquiry | |
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In these transgenic mice the L7/Pcp2 modified promoter directs tissue specific expression of cre in cerebellar Purkinje cells. A co-integrated GFP transgene results in GFP expression in the cerebellum.
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| STOCK Tg(Atoh1-cre/Esr1*)14Fsh/J (Cat. No.: CEMM-07250070) | Inquiry | |
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These knock-in mice express a tamoxifen-inducible cre recombinase from the endogenous promoter/enhancer elements of the atonal homolog 1 (Drosophila) (Atoh1, also referred to as Math1) gene. When induced, cre activity is observed in neural progenitors of the cerebellar rhombic lip, dorsal hindbrain and spinal cord, as well as in inner-ear primordial. These mice may be useful in studying cerebellum development and fate mapping of Math1/Atoh1 cells.
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| 129S.Cg-Ndor1Tg(UBC-cre/ERT2)1Ejb/J (Cat. No.: CEMM-07250062) | Inquiry | |
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When these UBC-Cre-ERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in widespread cells/tissues. In Goodwin et al. 2019 Genome Res. 29:494, it was discovered that the transgene integrated into chromosome 2 causing a 5 bp deletion in the NADPH dependent diflavin oxidoreductase 1 locus (Ndor1).
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| STOCK Tg(Nr5a1-cre)7Lowl/J (Cat. No.: CEMM-07250224) | Inquiry | |
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SF1-Cre transgenic mice have Cre recombinase expression detected in steroidogenic factor-1 (SF1)-positive neurons in the ventromedial hypothalamic nucleus as well as pituitary, gonad, and adrenal tissue. These mice may be useful for generating tissue specific-targeted mutants for studies of the subset of SF1-positive neurons, obesity, metabolic and energy homeostasis, and appetite control/satiety.
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| B6.129S6-Tg(CAG-Bgeo, -SMN2)E9Dscd/J (Cat. No.: CEMM-07250400) | Inquiry | |
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These Tg hSMN2 E9 inducible SMN transgenic mice conditionally express a human SMN2 cDNA. Widespread lacZ expression is observed except in those tissues where cre recombination has resulted in the human SMN2 cDNA to be expressed instead. These transgenic mice are suitable for use in studies related to Spinal Muscular Atrophy.
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| B6;129S-Tg(CAG-Bgeo, -MYC)1Saa/J (Cat. No.: CEMM-07250658) | Inquiry | |
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This strain is undergoing genetic quality control evaluation and is currently unavailable.Z-Myc transgenic mice conditionally express human c-Myc. Widespread lacZ expression is observed except in those tissues where Cre recombination has resulted in the human c-Myc to be expressed instead. These mice allow inducible c-Myc overexpression in specific tissues, and are useful in studying cancer.
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| C57BL/6J-Tg(CAG-lacZ, -FUS, -EGFP)629Gyu/J (Cat. No.: CEMM-07250646) | Inquiry | |
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The CAG-Z-FUSWT-IRES-EGFP transgenic line 629 [or CAG-Z-FUSWT (629)] has widespread expression of lacZ, that is replaced by expression of wildtype human fused in sarcoma protein (huFUSWT) and EGFP fluorescence following exposure to Cre recombinase. The Cre recombinase-inducible expression of huFUSWT, along with similarly designed transgenic mice harboring the FUSR521G mutant isoform, is useful in studying FUS-linked juvenile amyotrophic lateral sclerosis (ALS; Lou Gehrig's Disease), and the neurodegenerative disorder frontotemporal lobar degeneration (FTLD).
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For Research Use Only.