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STOCK Tg(Nr5a1-cre)7Lowl/J
Cat. No.: CEMM-07250224
Common Name: Sf1-Cre
SF1-Cre transgenic mice have Cre recombinase expression detected in steroidogenic factor-1 (SF1)-positive neurons in the ventromedial hypothalamic nucleus as well as pituitary, gonad, and adrenal tissue. These mice may be useful for generating tissue specific-targeted mutants for studies of the subset of SF1-positive neurons, obesity, metabolic and energy homeostasis, and appetite control/satiety.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Tg(Nr5a1-cre)7Lowl
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| Allele Name |
transgene insertion 7
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| Allele Attributes |
Recombinase-expressing
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| Gene Symbol |
Tg(Nr5a1-cre)7Lowl
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| Gene Name |
transgene insertion 7
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| Chromosome |
UN
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| Expressed Genes |
Cre, Cre recombinase, bacteriophage P1
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| MGI Accession ID | show more close |
| Site of Expression |
Cre mediated recombination is detected in steroidogenic factor-1 (SF1)-positive neurons in the ventromedial hypothalamic nucleus as well as pituitary, gonad, and adrenal tissue.
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| Strain of Origin |
FVB
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| Molecular Note |
This transgene includes Cre recombinase under the control of Nr5a1 regulatory sequences.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
FVB/NJ
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| Breeding Considerations |
When maintaining a live colony, transgenic mice may be bred to wildtype (non-carrier) mice from the colony or with FVB/NJ inbred mice. The Donating Investigator has not attempted to make the strain homozygous.
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| Breeding Strategy |
Hemizygote x Noncarrier; Noncarrier x Hemizygote
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| Coat Color |
Coat colors from mice of this strain may be either agouti or albino.
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For Research Use Only.
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