STOCK Tg(Neurog1-cre)1Jejo/J

Tg(Neurog1-cre)1Jejo

transgene insertion 1

Recombinase-expressing

Tg(Neurog1-cre)1Jejo

transgene insertion 1

UN

Cre, Cre recombinase, bacteriophage P1

4455179

When crossed with a reporter strain, Cre activity mimics the endogenous gene expression patterns in specific populations of interneurons and some motor neurons in the neural tube between embryonic days 10-13. Also, Cre recombination occurs in Neurog1 lineages that include subpopulations of neurons in the olfactory bulb, hippocampus, cortex, thalamus, midbrain, cerebellum, and dorsal root and cranial ganglia

(C57BL/6J x SJL/J)F1

The Neurog1 coding region in the BAC RP23 457E22 was replaced by recombineering methods with the coding sequence for Cre recombinase. Pronuclear injection of the construct into (C57BL/6J x SJL/J)F1 fertilized eggs was used to generated transgenic mice. Founder mice were subsequently established. The transgenic mice were then bred to outbred ICR mice. When crossed with a reporter strain, Cre activity mimics the endogenous gene expression patterns in specific populations of interneurons and some motor neurons in the neural tube between embryonic days 10-13. Also, Cre recombination occurs in Neurog1 lineages that include subpopulations of neurons in the olfactory bulb, hippocampus, cortex, thalamus, midbrain, cerebellum, and dorsal root and cranial ganglia.

Noncarrier

When maintaining a live colony, transgenic carrier mice may be bred with wildtype (non-carrier) mice from the colony. The Donating Investigator has not attempted to make the strain homozygous.