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STOCK Tg(Atoh1-cre/Esr1*)14Fsh/J

Cat. No.: CEMM-07250070

Common Name: Math1-CreERT2
These knock-in mice express a tamoxifen-inducible cre recombinase from the endogenous promoter/enhancer elements of the atonal homolog 1 (Drosophila) (Atoh1, also referred to as Math1) gene. When induced, cre activity is observed in neural progenitors of the cerebellar rhombic lip, dorsal hindbrain and spinal cord, as well as in inner-ear primordial. These mice may be useful in studying cerebellum development and fate mapping of Math1/Atoh1 cells.
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Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Tg(Atoh1-cre/Esr1*)14Fsh
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Allele Name
transgene insertion 14
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Allele Attributes
Recombinase-expressing; Inducible
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Gene Symbol
Tg(Atoh1-cre/Esr1*)14Fsh
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Gene Name
transgene insertion 14
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Chromosome
UN
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Expressed Genes
cre/Esr1, Cre recombinase and estrogen receptor 1 fusion gene
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MGI Accession ID
3615691
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Site of Expression
Tamoxifen-inducible Cre activity is observed in neural progenitors of the cerebellar rhombic lip, dorsal hindbrain and spinal cord, as well as in inner-ear primordia (with a limited amount of ectopic expression in the primordium of the hippocampus but not the cortex)
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Strain of Origin
FVB/N
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Molecular Note
The transgene was designed with a 1.4 kb mouse Math1 (Atoh1) 3' enhancer (and a beta-globin minimal promoter) sequence upstream of a CreERT2 fusion gene (Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain). Tamoxifen-inducible Cre activity is observed in neural progenitors of the cerebellar rhombic lip, dorsal hindbrain and spinal cord, as well as in inner-ear primordia (with a limited amount of ectopic expression in the primordium of the hippocampus but not the cortex).
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HUSBANDRY
Suggested Controls
FVB/NJ Noncarrier
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Breeding Considerations
When maintaining a live colony, transgenic mice can be bred to wildtype siblings or bred together, although a homozygous phenotype is not yet characterized (Aug-2007).
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For Research Use Only.
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