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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| STOCK Rapgef2tm1.1Hous/J (Cat. No.: CEMM-07250895) | Inquiry | |
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RapGEF2 flox (RapGEF2cko) mice possess loxP sites flanking exon 4 of the Rapgef2 gene. This strain may be useful for generating conditional mutations to study the role of RAPGEF2 in cell signaling in specific temporal/spatial situations.
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| C57BL/6-Gt(ROSA)26Sortm1(CAG-ECFP*/Rapgef3/Venus*)Kama/J (Cat. No.: CEMM-07250907) | Inquiry | |
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When these CAMPER, cAMP Encoded Reporter, mice are crossed with a Cre recombinase expressing strain, the floxed-STOP cassette is deleted and the Gt(ROSA)26Sor and CAG promoters drive expression of the TEpacVV cAMP sensor in the Cre-expressing cells. CAMPER mice allow selective cAMP concentration changes monitoring via FRET imaging in a tissue/cell-specific manner and may be useful in studies of G-protein-coupled receptors (GPCRs) responses.
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| B6.Cg-Igf2bp2tm1.1Thor/J (Cat. No.: CEMM-07250920) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking exons 4 and 5 of the Igf2bp2 gene. This strain may be useful for generating conditional mutations in applications related to the developing brain, neural stem cells, as well as metabolism and diabetes.
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| C57BL/6J-Grin2bem5Lutzy/J (Cat. No.: CEMM-07250925) | Inquiry | |
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This Grin2bflox CRISPR/Cas9 generated mutant of the Grin2b gene possesses loxP sites flanking 599 nucleotides (exon 4 of Ensembl transcript 201 and exon 5 of transcript 202). This strain may be useful for generating conditional mutations in applications related to neurodevelopment.
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| B6.129(Cg)-Wwtr1tm1Hmc/J (Cat. No.: CEMM-07250926) | Inquiry | |
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Tazflox floxed mutant mice possess loxP sites flanking exon 2 of the Wwtr1 gene. This strain may be useful for generating conditional mutations in applications related to the Hippo signaling pathway, organogenesis, tumorigenesis, and tumor suppression.
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| B6;129S-Sptan1tm1.1Mnr/J (Cat. No.: CEMM-07250951) | Inquiry | |
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Sptan1 floxed mice possess loxP sites flanking exon 8. This strain may be useful for generating conditional mutations in applications related to the study of the role played by Sptan1 and the cytoskeleton in neuronal development and neurodegeneration, as well as organization of the cytoskeleton.
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| STOCK Clstn3tm1.1Amcr/J (Cat. No.: CEMM-07251040) | Inquiry | |
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Clstn3f mice have loxP sites flanking exons 2-3 of the calsyntenin 3 gene. Exposure to Cre recombinase removes the floxed sequence - creating a null allele. These Clstn3f mice may be useful in studying synapse development and synaptic transmission.
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| C57BL/6J-Fcer1gem1Gfng/J (Cat. No.: CEMM-07251064) | Inquiry | |
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Fcer1g floxed mice have loxP sites flanking exons 2-3 of the Fc receptor, IgE, high affinity I, gamma polypeptide gene, which encodes the transmembrane domain. Exposure to Cre recombinase removes the floxed sequence - creating a null allele. These Fcer1g floxed mice may be useful in studying microglial expression and function.
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| STOCK Tg(dlx5a-cre)1Mekk/J (Cat. No.: CEMM-07250097) | Inquiry | |
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These Dlx5/6-Cre transgenic mice have Cre recombinase expression directed by the regulatory sequences of the zebrafish dlx5a/dlx6a genes and may be useful in generating specific deletions of floxed alleles in GABAergic in forebrain and other brain regions.
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| B6.129P2-Pvalbtm1(cre)Arbr/J (Cat. No.: CEMM-07250334) | Inquiry | |
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PV-Cre knock-in mice express Cre recombinase in parvalbumin-expressing neurons (such as interneurons in the brain and proprioceptive afferent sensory neurons in the dorsal root ganglia), without disrupting endogenous Pvalb expression. These mice may be useful in studying neuronal development, differentiation, and physiology.
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For Research Use Only.