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STOCK Rapgef2tm1.1Hous/J
Cat. No.: CEMM-07250895
Common Name: RapGEF2 flox (RapGEF2cko)
RapGEF2 flox (RapGEF2cko) mice possess loxP sites flanking exon 4 of the Rapgef2 gene. This strain may be useful for generating conditional mutations to study the role of RAPGEF2 in cell signaling in specific temporal/spatial situations.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Rapgef2tm1.1Hous
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Rapgef2
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| Gene Name |
Rap guanine nucleotide exchange factor (GEF) 2
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| Chromosome |
3
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| MGI Accession ID | show more close |
| Strain of Origin |
129S1/Sv-Oca2+ Tyr+ Kitl+
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| Molecular Note |
A loxP site was inserted upstream of exon 4 (originally numbered as exon 18) and an FRT and loxP flanked neo cassette was inserted downstream of exon 18. Flp mediated recombination removed the neo cassette leaving exon 18 floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J Wild-type from the colony
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| Breeding Considerations |
When maintaining a live colony, these mice can be bred as homozygotes.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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