STOCK Tg(dlx5a-cre)1Mekk/J

Cat. No.: CEMM-07250097

Common Name: Dlx5/6-Cre

These Dlx5/6-Cre transgenic mice have Cre recombinase expression directed by the regulatory sequences of the zebrafish dlx5a/dlx6a genes and may be useful in generating specific deletions of floxed alleles in GABAergic in forebrain and other brain regions.

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Status	Live Mouse Frozen Embryo
Age	4 weeks 12 weeks Customized Age
Sex	Male Female

GENETICS
Allele Symbol	Tg(dlx5a-cre)1Mekk show more close
Allele Name	transgene insertion 1 show more close
Allele Attributes	Recombinase-expressing show more close
Gene Symbol	Tg(dlx5a-cre)1Mekk show more close
Gene Name	transgene insertion 1 show more close
Chromosome	UN show more close
Expressed Genes	Cre, Cre recombinase, bacteriophage P1 show more close
MGI Accession ID	3758328 show more close
Site of Expression	GABAergic forebrain neurons show more close
Strain of Origin	CD-1 show more close
Molecular Note	A Cre gene was placed under the control of the I56i and I56ii enhancer elements of zebrafish dlx5a and a 3.5kb genomic DNA fragment flanking the 5' region of the zebrafish dlx6a open reading frame and containing the 5'UTR. The dlx6a flanking region on its own cannot produce tissue specific expression but inCreases the activity of the enhancers to produce expression that recapitulate endogenous Dlx5 expression. Tissue specific expression was confirmed by test crosses to reporter mice strains, including Tg(ACTB-Bgeo/ALPP)1Lbe, Tg(ACTB-Bgeo/GFP)21Lbe and Gt(ROSA)26Sortm1Sor. show more close

HUSBANDRY
Suggested Controls	Noncarrier show more close
Breeding Considerations	When maintaining a live colony, these mice can be bred as homozygotes. For Cre-lox experiments and to avoid/minimize germline deletion of the floxed allele, researchers may consider breeding Dlx5/6-Cre males to floxed females. show more close
Breeding Strategy	Noncarrier x Hemizygote show more close

For Research Use Only.