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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6.Cg-Slc1a2tm1.1Ncd/J (Cat. No.: CEMM-07250600) | Inquiry | |
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Flox-EAAT2 mice possess loxP sites flanking exons 3 and 4 of the Slc1a2 gene. This strain may be useful for generating conditional mutations in applications related to the regulation of excitatory glutamate neurotransmission, and the glutamate-glutamine cycle.
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| CBA;B6-Tg(Sox10-icre/ERT2)388Wdr/J (Cat. No.: CEMM-07250639) | Inquiry | |
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These Sox10-iCreERT2 mutant mice, carrying a transgene with tamoxifen-inducible optimized (improved) Cre recombinase under the control of the mouse Sox10 (SRY (sex determining region Y)-box 10) promoter, expresses iCreERT2 in oligodendrocyte lineage cells.
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| B6(SJL)-Pla2g6tm1c(EUCOMM)Hmgu/TurkMewJ (Cat. No.: CEMM-07250644) | Inquiry | |
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Exons 6 through 8 of the Pla2g6, phospholipase A2, group VI, gene is flanked by loxP sites in this conditional iPLA2β mutant strain. This strain may be useful for generating conditional mutations in applications related to the study of neurodegeneration, peripheral neuropathies and neuronal regeneration after injury.
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| B6.129(SJL)-Ntn1tm1.1Tek/J (Cat. No.: CEMM-07250651) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking the first protein encoding of the Ntn1 gene. Removal of the floxed sequence creates a null allele. This strain may be useful for generating conditional mutations in applications related to the regulation of neural development, axon guidance, cell migration and angiogenesis.
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| C57BL/6-Gt(ROSA)26Sortm1(CAG-GFP, -Mars*L274G)Esm/J (Cat. No.: CEMM-07250653) | Inquiry | |
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This STOPflox R26-MetRS* knock-in strain enables genetically targeted (Cre-dependent) metabolic labeling of endogenous proteins in specific cell-types in vivo for subsequent imaging or purification and biochemical analysis.
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| B6.129-Tcf3tm1Mbu/J (Cat. No.: CEMM-07250655) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking exons 17 through 19 of the Tcf3 gene, and a FRT site flanked GFP-NEO cassette downstream of exon 19. This strain may be useful for generating conditional mutations in applications related to hematopoiesis, and as a reporter for E2A (Tcf3) expression.
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| STOCK Dbx1tm2Jcor/J (Cat. No.: CEMM-07250656) | Inquiry | |
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These Dbx1flox mutant mice possess loxP sites flanking exons 2 through 4 of the Dbx1 gene. This strain may be useful for generating conditional mutations in applications related to CNS neuronal progenitor subpopulation fate mapping.
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| B6.129S6-Apoetm1.1Mae/MazzJ (Cat. No.: CEMM-07250670) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking exon 3 of the Apoe gene. This strain may be useful for generating conditional mutations in applications related to the regulation of lipoprotein and cholesterol metabolism, neurovascular function, inflammation and in the pathophysiology of neurodegenerative cardiovascular diseases.
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| FVB.129(B6)-Slc44a2tm1.1Tec/J (Cat. No.: CEMM-07250689) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking exons 3 through 10 of the Slc44a2 gene, also known as Ctl2. This strain may be useful for generating conditional mutations in applications related to cochlear hair cell survival and antibody-induced hearing loss.
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| B6.Cg-Relbtm1Ukl/J (Cat. No.: CEMM-07250693) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking exons 1 and 2 of the Relb gene. This strain may be useful for generating conditional mutations in applications related to the study of the B-cell nuclear factor-ΚB (NF-ΚB) pathway. Cre-mediated recombination also results in expression of GFP (Green Fluorescent Protein) which can be used to trace Relb ablation.
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For Research Use Only.