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B6.129(SJL)-Ntn1tm1.1Tek/J
Cat. No.: CEMM-07250651
Common Name: netrin-1 floxed
These floxed mutant mice possess loxP sites flanking the first protein encoding of the Ntn1 gene. Removal of the floxed sequence creates a null allele. This strain may be useful for generating conditional mutations in applications related to the regulation of neural development, axon guidance, cell migration and angiogenesis.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Ntn1tm1.1Tek
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Ntn1
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| Gene Name |
netrin 1
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| Chromosome |
11
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| MGI Accession ID | show more close |
| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
The targeting vector contains a FRT flanked Neo selection cassette and a loxP site inserted downstream of the first protein coding exon of the targeted gene, and another loxP site was inserted upstream of the first protein coding exon. FLP-mediated recombination removed the FRT flanked neo cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, these mice can be bred as homozygotes.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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