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B6(SJL)-Pla2g6tm1c(EUCOMM)Hmgu/TurkMewJ
Cat. No.: CEMM-07250644
Common Name: Pla2g6 flox
Exons 6 through 8 of the Pla2g6, phospholipase A2, group VI, gene is flanked by loxP sites in this conditional iPLA2β mutant strain. This strain may be useful for generating conditional mutations in applications related to the study of neurodegeneration, peripheral neuropathies and neuronal regeneration after injury.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Pla2g6tm1c(EUCOMM)Hmgu
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| Allele Name |
targeted mutation 1c
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Pla2g6
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| Gene Name |
phospholipase A2
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| Chromosome |
15
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6N-Atm1Brd
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| Molecular Note |
The mutant allele has, from 5' to 3', an FRT site, an En2 splice acceptor cassette containing IRES, beta-galactosidase and polyA sequence, a loxP site, human beta-actin promoter, SV40 polyA, a second FRT site, and a second loxP site inserted upstream of exon 6. A third loxP-site is inserted downstream of exon 8. Flp-mediated recombination removed the FRT flanked neo cassette and En2 splice acceptor leaving exons 6 through 8 floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, these mice can be bred as homozygotes.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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