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B6.Cg-Relbtm1Ukl/J

Cat. No.: CEMM-07250693

Common Name: Relb flox
These floxed mutant mice possess loxP sites flanking exons 1 and 2 of the Relb gene. This strain may be useful for generating conditional mutations in applications related to the study of the B-cell nuclear factor-ΚB (NF-ΚB) pathway. Cre-mediated recombination also results in expression of GFP (Green Fluorescent Protein) which can be used to trace Relb ablation.
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Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Relbtm1Ukl
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Allele Name
targeted mutation 1
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Allele Attributes
Conditional ready (e.g. floxed); Reporter; No functional change
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Gene Symbol
Relb
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Gene Name
avian reticuloendotheliosis viral (v-rel) oncogene related B
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Chromosome
7
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Expressed Genes
GFP, Green Fluorescent Protein
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MGI Accession ID
5788155
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Site of Expression
When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have GFP expression in the Cre-expressing tissues.
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Strain of Origin
(C57BL/6J x 129S6/SvEvTac)F1
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Molecular Note
Sequence encoding a promoterless eGFP minigene, a loxP site and the PGKneo cassette is inserted upstream of exon 1 (containing the translation start site), and another loxP site followed by the PGK promoter is inserted downstream of exon 2. The entire targeted region is flanked by FRT sites. Recombination using Cre recombinase will remove the exons while allowing EGFP expression or FLP-mediated recombination will remove both the exons and the EGFP.
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HUSBANDRY
Suggested Controls
C57BL/6J
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Breeding Considerations
When maintaining a live colony, these mice can be bred as homozygotes.
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Breeding Strategy
Homozygote x Homozygote
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For Research Use Only.
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