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B6.Cg-Slc1a2tm1.1Ncd/J
Cat. No.: CEMM-07250600
Common Name: Flox-EAAT2; Flox-GLT-1
Flox-EAAT2 mice possess loxP sites flanking exons 3 and 4 of the Slc1a2 gene. This strain may be useful for generating conditional mutations in applications related to the regulation of excitatory glutamate neurotransmission, and the glutamate-glutamine cycle.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Slc1a2tm1.1Ncd
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Slc1a2
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| Gene Name |
solute carrier family 1 (glial high affinity glutamate transporter)
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| Chromosome |
2
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| MGI Accession ID | show more close |
| Strain of Origin |
(129S6/SvEvTac x C57BL/6J)F1
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| Molecular Note |
A loxP site was inserted into intron 2 and an FRT neo-FRT loxP cassette was inserted into intron 4, floxing exons 3 and 4 of the Slc1a2 gene from the bacterial artificial chromosome clone RP24-315H4. The neomycin cassette was removed via FLP-mediated recombination, leaving exons 3 and 4 floxed by loxP sites. Cre-mediated recombination can be used to remove exons 3 and 4 which results in a frameshift deletion.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, these mice can be bred as homozygotes.
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For Research Use Only.
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