Mouse Models

Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.

For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.

Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.

If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.

Our Mouse Models

Reporter Mouse

Floxed Mouse

Recombinase-expressing Mouse

Inducible Mouse

B6.Cg-Igs7^{tm94.1(tetO-GCaMP6s)Hze} Tg(Camk2a-tTA)1Mmay/J (Cat. No.: CEMM-07250533)		Inquiry
Ai94(TITL-GCaMP6s)-D;CaMK2a-tTA (or Ai94D;CaMK2a-tTA) mice have a Cre/Tet-dependent, fluorescent calcium indicator GCaMP6s inserted into the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated), as well as a transgene directing tetracycline-controlled transactivator protein (tTA) expression in forebrain neurons. After removal of the floxed-STOP cassette by Cre recombinase, resulting mice have doxycycline-inducible/reversible expression of GCaMP6 slow variant calcium indicator (GCaMP6s; an ultrasensitive detector of single neuronal action potentials with slower decay and response kinetics). Following subsequent calcium binding (such as neuronal activation), increased EGFP fluorescence is observed in those cells. As described for, the CaMK2a-tTA transgene integrated into chromosome 12 causing a 508 Kb deletion that spans the 3' half of Vipr2, the entire Wdr60, Esyt2, D430020J02Rik and Ncapg2 loci and the first two exons of Ptprn2. Homozygous mice will therefore have a functional knock-out of the deleted loci, and altered or null expression of Vipr2 and Ptprn2. Founder line 1 has >20 transgene copies. show more close

B6N.129P2(Cg)-Igs13^tm1Dolm Igs14^tm1Dolm/J (Cat. No.: CEMM-07250561)		Inquiry
A copy number variation on human chromosome 16p11.2 is among the most common genetic variations found in autism spectrum disorders. 16p11flx mice are a Cre or FLP recombinase-inducible mouse model of 16p11.2 deletion that has several loxP and frt sites flanking the corresponding 440 kbp region on mouse chromosome 7F3. These mice may be useful in studying basal ganglia circuitry and the pathophysiology of autism. show more close

STOCK Mc4r^tm2.2Lowl/J (Cat. No.: CEMM-07250513)		Inquiry
Mc4rflox mice possess loxP sites flanking the entire coding region of the melanocortin 4 receptor (Mc4r) gene. These mice may be useful when studying neurobiology, obesity, diabetes, hunger/appetite, and fat and energy metabolism. show more close

B6.129S1-Ddah1^tm1Yjch/J (Cat. No.: CEMM-07250610)		Inquiry
The DDAH1flox allele has loxP sites flanking exon 4 of the dimethylarginine dimethylaminohydrolase 1 gene. Removal of the floxed sequence creates a null allele. These mice may be used to manipulate DDAH1 expression for studying methylarginine (ADMA and L-NMMA) accumulation and systemic nitric oxide bio-availability in several disorders, including cardiovascular disease and diabetes. show more close

C57BL/6-Pabpn1^tm2.1Gpvl/J (Cat. No.: CEMM-07250717)		Inquiry
Pabpn1 floxed mice possess a loxP sited flanking exons 1-2, including the start codon, of the poly(A) binding protein, nuclear 1 (Pabpn1) gene. These mice may be useful when studying Oculopharyngeal muscular dystrophy (OPMD). show more close

STOCK Raph1^tm1.1Fbg/J (Cat. No.: CEMM-07250750)		Inquiry
Lpdflox mice possess loxP sites flanking the entire coding region of the Raph1 gene. These mice may be useful in studying actin dynamics during neurodevelopment and rectal carcinomas. show more close

FVB.129P2-Glul^tm3Whla/J (Cat. No.: CEMM-07250761)		Inquiry
GSfl/fl floxed mice possess loxP sites flanking exons 1-7 of the Glul gene. This strain may be useful for studying the role of glutamine synthetase in ammonia detoxification. show more close

B6.Cg-Slc6a13^tm1.1Ncd/J (Cat. No.: CEMM-07250768)		Inquiry
GAT2-flox mice possess loxP sites flanking exons 5-7 of the neurotransmitter transporter, GABA gene. This strain may be useful for studying the role of GABA neurotransmitter and taurine levels in the brain. show more close

B6.129-Rcor2^tm1.1Gman/J (Cat. No.: CEMM-07250771)		Inquiry
Rcor2fl/fl mice possess loxP sites flanking exons 5-9 of the REST corepressor 2 gene. These mice may be useful in studying the proliferation and differentiation of neural progenitor cells during brain development. show more close

B6J.129S-Slc6a12^tm1.1Ncd/J (Cat. No.: CEMM-07250776)		Inquiry
BGT1-flox mice possess loxP sites flanking exons 3-5 of the solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 gene. This strain may be useful for studying the role of BGT1 in the brain and liver. show more close

For Research Use Only.