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FVB.129P2-Glultm3Whla/J
Cat. No.: CEMM-07250761
Common Name: GSfl
GSfl/fl floxed mice possess loxP sites flanking exons 1-7 of the Glul gene. This strain may be useful for studying the role of glutamine synthetase in ammonia detoxification.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Glultm3Whla
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| Allele Name |
targeted mutation 3
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Glul
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| Gene Name |
glutamate-ammonia ligase (glutamine synthetase)
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| Chromosome |
1
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| MGI Accession ID | show more close |
| Site of Expression |
Glutamate-ammonia ligase (glutamine synthetase) is normally expressed in glutamine-consuming organs such as the nervous system, kidney, muscle, and liver.
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| Strain of Origin |
129P2/OlaHsd
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| Molecular Note |
One loxP site was inserted in the 3' end of intron 1. An FRT flanked Pgk-neo-PgkTkselection casette was inserted along with a second loxP site 600 bp downstream from exon 7. The FRT flanked selection cassette was removed by transient transfection using an FLPe expression vector.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
FVB/NJ
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| Breeding Considerations |
When maintaining a live colony, mice homozygous for the floxed allele may be bred together.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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