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B6.129S1-Ddah1tm1Yjch/J
Cat. No.: CEMM-07250610
Common Name: DDAH1flox
The DDAH1flox allele has loxP sites flanking exon 4 of the dimethylarginine dimethylaminohydrolase 1 gene. Removal of the floxed sequence creates a null allele. These mice may be used to manipulate DDAH1 expression for studying methylarginine (ADMA and L-NMMA) accumulation and systemic nitric oxide bio-availability in several disorders, including cardiovascular disease and diabetes.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Ddah1tm1Yjch
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Ddah1
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| Gene Name |
dimethylarginine dimethylaminohydrolase 1
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| Chromosome |
3
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| MGI Accession ID | show more close |
| Strain of Origin |
129S1/Sv-Oca2+ Tyr+ Kitl+
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| Molecular Note |
Exon 4 was flanked by loxP sites and an FRT flanked neomycin selection cassette was inserted immediately downstream of the loxP site in intron 4.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J Wild-type from the colony
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| Breeding Considerations |
When maintaining a live colony, mice homozygous for the floxed allele may be bred together.
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For Research Use Only.
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