Online Inquiry
C57BL/6-Pabpn1tm2.1Gpvl/J
Cat. No.: CEMM-07250717
Common Name: Pabpn1 floxed
Pabpn1 floxed mice possess a loxP sited flanking exons 1-2, including the start codon, of the poly(A) binding protein, nuclear 1 (Pabpn1) gene. These mice may be useful when studying Oculopharyngeal muscular dystrophy (OPMD).
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Pabpn1tm2.1Gpvl
show more
close
|
| Allele Name |
targeted mutation 2.1
show more
close
|
| Allele Attributes |
Conditional ready (e.g. floxed)
show more
close
|
| Gene Symbol |
Pabpn1
show more
close
|
| Gene Name |
poly(A) binding protein
show more
close
|
| Chromosome |
14
show more
close
|
| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6
show more
close
|
| Molecular Note |
A loxP site was inserted upstream of exon 1 and an FRT site flanked puromycin resistance gene cassette and a second loxP site into intron 2. The puro cassette was removed through subsequent Flp-mediated recombination. Exons 1 and 2 were deleted through Cre-mediated recombination, Creating a null allele.
show more
close
|
| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
show more
close
|
| Breeding Considerations |
When maintaining a live colony, mice homozygous for the floxed allele may be bred together.
show more
close
|
For Research Use Only.
Related Products