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STOCK Mc4rtm2.2Lowl/J
Cat. No.: CEMM-07250513
Common Name: Mc4rflox
Mc4rflox mice possess loxP sites flanking the entire coding region of the melanocortin 4 receptor (Mc4r) gene. These mice may be useful when studying neurobiology, obesity, diabetes, hunger/appetite, and fat and energy metabolism.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Mc4rtm2.2Lowl
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| Allele Name |
targeted mutation 2.2
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Mc4r
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| Gene Name |
melanocortin 4 receptor
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| Chromosome |
18
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| MGI Accession ID | show more close |
| Strain of Origin |
129S6/SvEvTac
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| Molecular Note |
One loxP site was inserted in the 5'UTR and a second loxP site followed by a FRT flanked kanamycin resistance cassette was inserted in the 3'UTR. The single coding exon is thus flanked by loxP sites. Flp-mediated recombination removed the FRT flanked kanamycin cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
B6129SF2/J
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| Breeding Considerations |
When maintaining a live colony, mice homozygous for the floxed allele may be bred together.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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