Online Inquiry
Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6.FVB-Tg(Otp-cre)1Hzo/J (Cat. No.: CEMM-07250815) | Inquiry | |
|
These Otp-cre mice express Cre recombinase in hypothalamic and medial amygdala neurons.
show more
close
|
||
| B6J.FVB(129)-Tg(Nr5a1-cre)7Lowl/RujfJ (Cat. No.: CEMM-07250957) | Inquiry | |
|
Sf1-Cre transgenic mice express Cre recombinase under the direction of the mouse Nr5a1 (nuclear receptor subfamily 5, group A, member 1) promoter. Cre expression is detected in steroidogenic factor-1 (SF1)-positive neurons in the ventromedial hypothalamic nucleus as well as pituitary, gonad, and adrenal tissue. These mice may be useful for generating tissue specific-targeted mutants for studies of the subset of SF1-positive neurons, obesity, metabolic and energy homeostasis, and appetite control/saeity. This line has been backcrossed to C57BL/6J for more than 10 generations by the donating laboratory.
show more
close
|
||
| C57BL/6J-Tg(Cbln1-cre)NIDA169Htz/Mmjax (Cat. No.: CEMM-07250864) | Inquiry | |
|
These BAC transgenic mice express Cre recombinase from the mouse Cbln1 (cerebellin 1 precursor protein) gene. Recombination has been observed in mitral neurons in the olfactory bulb, projection neurons in the entorhinal cortex and granule neurons in the cerebellum.
show more
close
|
||
| C57BL/6J-Tg(Dcdc2a-cre)NIDA056Htz/Mmjax (Cat. No.: CEMM-07250865) | Inquiry | |
|
These BAC transgenic mice express Cre recombinase from the mouse Dcdc2a gene (doublecortin domain containing 2a). Recombination has been observed in ependymal cells lining the ventricle of the brain, the choroid plexus, and tanycytes in the third ventricle.
show more
close
|
||
| B6N.FVB-Tg(Slc6a11-cre/ERT2)1Khakh/J (Cat. No.: CEMM-07250746) | Inquiry | |
|
Slc6a11-Cre/ERT2 BAC transgenic mice have tamoxifen-inducible Cre recombinase expression directed at moderate levels to astrocytes and neurons. These mice allow inducible genetic manipulations in vivo for studying astrocyte and neuron biology of GAT3+ cells.
show more
close
|
||
| STOCK Tg(Ccna2-lacZ, -EGFP)1Sev/J (Cat. No.: CEMM-07250796) | Inquiry | |
|
The CyclinA2-lacZ-EGFP BAC transgenic mouse line (or CyclinA2-floxed:LacZ-GFP) is a robust and sensitive reporter of cell cycle activity in any cell type of interest - enabling the visualization of cell cycle activity in specific cell types. These CyclinA2-fusion reporter mice are designed to express CyclinA2-lacZ (CyclinA2-βgal) prior to Cre recominase exposure, and CyclinA2-EGFP following Cre recombination.
show more
close
|
||
| B6;129-Syt11tm1Sud/J (Cat. No.: CEMM-07250101) | Inquiry | |
|
Exon 2 of the mouse Syt11 (synaptotagmin XI) gene carries a Flag tag insertion and is flanked by loxP sites in this Syt11 knock-in allele. Cre recombinase-mediated excision of the floxed exon results in a knock-out of the gene, useful in studies of neurotransmitter release mechanisms.
show more
close
|
||
| B6;129-Vangl1tm1.1Nat/J (Cat. No.: CEMM-07250422) | Inquiry | |
|
The third (and largest) coding exon of Vangl1 (vang-like 1 (van gogh, Drosophila)) is flanked by loxP sites in this conditional knockout allele.
show more
close
|
||
| B6N.129S1-Mrgprb4tm3(cre)And/J (Cat. No.: CEMM-07250436) | Inquiry | |
|
The entire open reading frame of the Mrgprb4 (MAS-related GPR, member B4) gene was replaced by an mtdTomato-2A-NLSCre-Frt-PGK-Neomycin-FRT cassette in these knockout/knock-in allele mutant mice. When virally transduced, they are useful in studies of Mrgprb4-expressing sensory neurons. Constitutive expression of mtdTomato has been demonstrated in dorsal root ganglion (DRG) cells.
show more
close
|
||
| STOCK Zfp335tm1.1Caw/J (Cat. No.: CEMM-07250478) | Inquiry | |
|
Zfp335 (zinc finger protein 335; also known as identified as a NRC-interacting factor 1 (Nif1)) is a regulator of vertebrate neurogenesis. This mutant in the human gene is associated with severe microcephaly, neuronal degeneration, and neonatal death. The mouse Zfp335 promoter, exon 1, and exon 2 are flanked by loxP sites in this conditional targeted mutation strain, enabling tissue-specific knockouts mediated by Cre recombinase.
show more
close
|
||
For Research Use Only.