B6J.FVB(129)-Tg(Nr5a1-cre)7Lowl/RujfJ

Cat. No.: CEMM-07250957

Common Name: B6J.Cg-Tg(Nr5a1-cre)7Lowl/RujfJ

Sf1-Cre transgenic mice express Cre recombinase under the direction of the mouse Nr5a1 (nuclear receptor subfamily 5, group A, member 1) promoter. Cre expression is detected in steroidogenic factor-1 (SF1)-positive neurons in the ventromedial hypothalamic nucleus as well as pituitary, gonad, and adrenal tissue. These mice may be useful for generating tissue specific-targeted mutants for studies of the subset of SF1-positive neurons, obesity, metabolic and energy homeostasis, and appetite control/saeity. This line has been backcrossed to C57BL/6J for more than 10 generations by the donating laboratory.

Inquiry

Status	Live Mouse Frozen Embryo
Age	4 weeks 12 weeks Customized Age
Sex	Male Female

GENETICS
Allele Symbol	Tg(Nr5a1-cre)7Lowl show more close
Allele Name	transgene insertion 7 show more close
Allele Attributes	Recombinase-expressing show more close
Gene Symbol	Tg(Nr5a1-cre)7Lowl show more close
Gene Name	transgene insertion 7 show more close
Chromosome	UN show more close
Expressed Genes	Cre, Cre recombinase, bacteriophage P1 show more close
MGI Accession ID	3617315 show more close
Site of Expression	Cre mediated recombination is detected in steroidogenic factor-1 (SF1)-positive neurons in the ventromedial hypothalamic nucleus as well as pituitary, gonad, and adrenal tissue. show more close
Strain of Origin	FVB show more close
Molecular Note	This transgene includes Cre recombinase under the control of Nr5a1 regulatory sequences. show more close

HUSBANDRY
Suggested Controls	C57BL/6J Noncarrier show more close
Breeding Considerations	Hemizygotes are viable and fertile. The Donating Investigator has not attempted to make the strain homozygous. show more close
Breeding Strategy	Noncarrier x Hemizygote; Hemizygote x Noncarrier show more close

For Research Use Only.