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STOCK Zfp335tm1.1Caw/J

Cat. No.: CEMM-07250478

Zfp335 (zinc finger protein 335; also known as identified as a NRC-interacting factor 1 (Nif1)) is a regulator of vertebrate neurogenesis. This mutant in the human gene is associated with severe microcephaly, neuronal degeneration, and neonatal death. The mouse Zfp335 promoter, exon 1, and exon 2 are flanked by loxP sites in this conditional targeted mutation strain, enabling tissue-specific knockouts mediated by Cre recombinase.
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Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Zfp335tm1.1Caw
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Allele Name
targeted mutation 1.1
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Allele Attributes
Conditional ready (e.g. floxed); No functional change
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Gene Symbol
Zfp335
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Gene Name
zinc finger protein 335
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Chromosome
2
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MGI Accession ID
5470136
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Strain of Origin
(129S6/SvEvTac x C57BL/6J)F1
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Molecular Note
Exons 1 and 2 were floxed. Flp-mediated recombination removed the FRT flanked neo cassette inserted downstream of exon 2.
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HUSBANDRY
Suggested Controls
C57BL/6J Wild-type from the colony
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Breeding Considerations
Heterozygotes and homozygotes are viable and fertile.
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Breeding Strategy
Wild-type x Heterozygote; Heterozygote x Wild-type
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For Research Use Only.
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