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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6.Cg-Parm1em1(cre)Ngai/TasicJ (Cat. No.: CEMM-07251103) | Inquiry | |
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Parm1-P2A-Cre knock-in mice are designed to have Cre recombinase expression/activity directed by the endogenous prostate androgen-regulated mucin-like protein 1 promoter/enhancer sequences. These mice may be used to generate conditional mutations for studying function of Parm1-expressing cells.
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| B6.Cg-Rxfp1em1(cre)Ngai/TasicJ (Cat. No.: CEMM-07251104) | Inquiry | |
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Rxfp1-P2A-Cre knock-in mice are designed to have Cre recombinase expression/activity directed by the endogenous relaxin/insulin-like family peptide receptor 1 promoter/enhancer sequences. These mice may be used to generate conditional mutations for studying function of Rxfp1-expressing cells.
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| B6.Cg-Slco2a1em1(cre)Ngai/TasicJ (Cat. No.: CEMM-07251105) | Inquiry | |
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Slco2a1-P2A-Cre knock-in mice are designed to have Cre recombinase expression/activity directed by the endogenous solute carrier organic anion transporter family member 2a1 promoter/enhancer sequences. These mice may be used to generate conditional mutations for studying function of Slco2a1-expressing cells.
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| B6.129P2-Myd88tm1Hlz/J (Cat. No.: CEMM-07250706) | Inquiry | |
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The MyD88LSL knock-in/knock-out allele is a functional null prior to Cre recombinase exposure. These mice allow Cre recombinase-inducible restoration of functional MYD88 expression. MyD88LSL mice may be useful for studying cell-type-specific function of MYD88 in immune system abnormalities, as well as hematopoietic system and apoptotic abnormalities.
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| STOCK Cul3tm1Jdsr/J (Cat. No.: CEMM-07250663) | Inquiry | |
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Cul3flox (loxP::frt-neo-frt::exons4-7::loxP) is a cullin 3 hypomorphic allele that is converted to a null allele after Cre recombinase exposure. These mice may be useful in studying the function of cullin-RING-based BTB-CUL3-RBX1 E3 ubiquitin-protein ligase complexes in multiple areas, including autism and cancer.
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| B6.129X1(FVB)-Nr1h4tm1.2Gonz/J (Cat. No.: CEMM-07250664) | Inquiry | |
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Fxrfl (loxP::exon::loxP::Δneo) is a floxed allele - loxP sites flank the last exon of the Nr1h4 gene. Removal of the floxed sequence creates a null allele. These mice may be useful in studying metabolic disorders, as well as the regulation of bile acid, lipid and glucose metabolism. Δneo)
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| B6.129(Cg)-Csnk1a1tm1.1Ybn/J (Cat. No.: CEMM-07250562) | Inquiry | |
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These CsnK1a1fl floxed mice allow Cre recombinase-inducible knockout of casein kinase Ia (CKIα) for studying multiple cellular processes (Wnt pathway, cell cycle regulation, DNA damage response, KRAS-MEK-ERK mitogenic signaling, β-catenin-destruction complex) in cancer and senescence-associated inflammatory response (SIR)/para-inflammation suppression.
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| B6;129S-Gt(ROSA)26Sortm1(Cdkn1c)Jfpa/J (Cat. No.: CEMM-07250475) | Inquiry | |
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R26loxpTA-p57 mice allow Cre recombinase-inducible expression of the cell cycle inhibitor p57Kip2 (Cdkn1c), resulting in cell cycle arrest in G1 phase of the cre expressing cells.
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| B6.129S6(Cg)-Nkx2-2tm4.1(cre/EGFP)Suss/J (Cat. No.: CEMM-07250618) | Inquiry | |
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These Nkx2-2:Cre-EGFP knock-in/knockout mice may have applications in studies requiring conditional gene manipulation or lineage fate mapping in the CNS, pancreas and intestine.
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| STOCK Tg(Pou4f1-cre/ERT2)2Jiz/J (Cat. No.: CEMM-07250923) | Inquiry | |
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brn3a-CreERT2 transgenic mice have the mouse Pou4f1 gene promoter directing expression of tamoxifen-inducible Cre recombinase, and may be useful for mediating inducible Cre recombination in Pou4f1-expressing tissues, including sensory neurons.
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For Research Use Only.