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B6.129X1(FVB)-Nr1h4tm1.2Gonz/J
Cat. No.: CEMM-07250664
Common Name: Fxrfl (loxP::exon::loxP::Δneo)
Fxrfl (loxP::exon::loxP::Δneo) is a floxed allele - loxP sites flank the last exon of the Nr1h4 gene. Removal of the floxed sequence creates a null allele. These mice may be useful in studying metabolic disorders, as well as the regulation of bile acid, lipid and glucose metabolism. Δneo)
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Nr1h4tm1.2Gonz
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| Allele Name |
targeted mutation 1.2
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Nr1h4
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| Gene Name |
nuclear receptor subfamily 1
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| Chromosome |
10
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| MGI Accession ID | show more close |
| Strain of Origin |
129X1/SvJ
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| Molecular Note |
The targeting construct contains a loxP site inserted in the intron 5' to the last exon and a loxP-flanked neomycin cassette inserted 3' to the last exon. Germline Cre-mediated recombination removed the floxed neo cassette leaving the last exon floxed. The last exon encodes the ligand binding domain and all of the 3' untranslated region.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6NJ
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| Breeding Considerations |
When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6NJ inbred mice. Alternatively, homozygous mice may be bred together.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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