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STOCK Cul3tm1Jdsr/J

Cat. No.: CEMM-07250663

Common Name: Cul3flox
Cul3flox (loxP::frt-neo-frt::exons4-7::loxP) is a cullin 3 hypomorphic allele that is converted to a null allele after Cre recombinase exposure. These mice may be useful in studying the function of cullin-RING-based BTB-CUL3-RBX1 E3 ubiquitin-protein ligase complexes in multiple areas, including autism and cancer.
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Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Cul3tm1Jdsr
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Allele Name
targeted mutation 1
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Allele Attributes
Conditional ready (e.g. floxed); No functional change
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Gene Symbol
Cul3
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Gene Name
cullin 3
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Chromosome
1
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MGI Accession ID
3714267
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Strain of Origin
129S4/SvJaeSor
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Molecular Note
Exons 4-7 were flanked with loxP sites. An FRT flanked neo was included in intron 3.
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HUSBANDRY
Suggested Controls
C57BL/6NJ
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Breeding Considerations
When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6NJ inbred mice. Alternatively, homozygous mice may be bred together.
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Breeding Strategy
Homozygote x Homozygote
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For Research Use Only.
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