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B6.129(Cg)-Csnk1a1tm1.1Ybn/J
Cat. No.: CEMM-07250562
Common Name: CsnK1a1fl
These CsnK1a1fl floxed mice allow Cre recombinase-inducible knockout of casein kinase Ia (CKIα) for studying multiple cellular processes (Wnt pathway, cell cycle regulation, DNA damage response, KRAS-MEK-ERK mitogenic signaling, β-catenin-destruction complex) in cancer and senescence-associated inflammatory response (SIR)/para-inflammation suppression.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Csnk1a1tm1.1Ybn
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Csnk1a1
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| Gene Name |
casein kinase 1
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| Chromosome |
18
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| MGI Accession ID | show more close |
| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
A floxed neomycin resistance cassette was inserted upstream of exon 1. An additional loxP site was inserted downstream of exon 2. Cre-mediated recombination removed the neomycin resistance cassette and left exons 1 and 2 floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J C57BL/6NJ
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| Breeding Considerations |
When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony, or to C57BL/6J inbred mice. Alternatively, homozygous mice may be bred together.
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For Research Use Only.
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