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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| STOCK Cnih3tm1.1Ran/J (Cat. No.: CEMM-07250668) | Inquiry | |
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The Cnih3fl floxed allele has loxP sites flanking exon 4 of the cornichon-3 gene. Removal of the floxed sequence creates a null allele. These mice may be useful in studying the role of synaptic glutamate AMPA receptors in hippocampal synaptic transmission/plasticity, nociception and behavioral, social and cognitive abnormalities, as well as neuropsychiatric disorders such as schizophrenia and depression/mania.
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| STOCK Gt(ROSA)26Sortm1(CAG-EGFP)Fsh/Mmjax (Cat. No.: CEMM-07250186) | Inquiry | |
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These RCE:dual mice harbor the R26R CAG-boosted EGFP reporter allele with both a loxP-flanked STOP cassette and FRT-flanked STOP cassette upstream of the EGFP gene. After removal of the flanked STOP cassettes via cre- and Flp-mediated recombination, the EGFP reporter is expressed in cells/tissues where the expression patterns of the individual promoters driving Cre recombinase and FLP recombinase overlap.
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| STOCK Gt(ROSA)26Sortm1.1(CAG-EGFP)Fsh/Mmjax (Cat. No.: CEMM-07250197) | Inquiry | |
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These RCE:loxP mice harbor the R26R CAG-boosted EGFP (RCE) reporter allele with a loxP-flanked STOP cassette upstream of the enhanced green fluorescent protein (EGFP) gene. After removal of the loxP-flanked STOP cassette by cre-mediated recombination, EGFP reporter expression is directed to the cells/tissues dependent upon expression pattern of the promoter driving Cre recombinase.
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| B6;129S-Nos1tm1.1(cre/ERT2)Zjh/J (Cat. No.: CEMM-07250292) | Inquiry | |
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The nNOS-CreER-KI knock-in allele was designed to both abolish neuronal nitric oxide synthase 1 (Nos1) gene function and direct CreERT2 fusion protein expression to nNOS positive GABAergic neurons by the endogenous Nos1 promoter/enhancer elements. Cre-ERT2 fusion gene activity is inducible by tamoxifen administration.
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| STOCK En2tm4(cre/ERT2)Alj/J (Cat. No.: CEMM-07250087) | Inquiry | |
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En2-CreERT2 mutant mice harbor the Cre-ERT2 fusion gene under control of the endogenous engrailed 2 locus. When En2-CreERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in En2-expressing tissues (including the developing mesencephalon, rhombomere 1, and jaw muscles, as well as the embryonic and adult cerebellum).
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| STOCK En2tm5.1Alj/J (Cat. No.: CEMM-07250088) | Inquiry | |
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These En2flox-taulacZ (En2-floxLacZ, En2tau-lacZ, or En2-tau-lacZ) mutant mice harbor a loxP-flanked tau β-galactosidase "knock-in" allele that also abolishes engrailed 2 (En2) gene function, and may be useful for conditional reporter protein expression in En2-expressing tissues (including the early mesencephalon and rhombomere 1, and developing cerebellum and jaw muscles), as well as for conditional restoration of En2 function.
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| STOCK Klf9tm2Sahay/J (Cat. No.: CEMM-07251122) | Inquiry | |
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Klf9fl conditional mutant mice possess loxP sites flanking exon 1 of the Klf9 (Kruppel-like factor 9) gene and may be useful in generating conditional mutations to study stem cell regulation.
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| B6(Cg)-H3c6em1Sjes/J (Cat. No.: CEMM-07251099) | Inquiry | |
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H3.1-iCOUNT (inducible cell division counter) knock-in mice carry a loxP-flanked mCherry reporter followed by an EGFP reporter inserted upstream of the H3c6 (H3 clustered histone 6, also called H3.1) stop codon. Mice may be used to label cell division events in vivo.
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| B6J.B6N-Gt(ROSA)26Sorem1(CAG-APPIbe)Jjan/J (Cat. No.: CEMM-07251100) | Inquiry | |
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These R26-APPIbe mice harbor an endonuclease mediated mutation in the Gt(ROSA)26Sor locus with a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven human APP (amyloid beta (A4) precursor protein) cDNA containing the Iberian (I716F) mutation. APPIbe is only expressed following cre-mediated recombination. This strain provides spatial and temporal control of mutant APP expression for studies of Alzheimer's Disease.
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| B6;129S-Klf9tm1.1Sahay/J (Cat. No.: CEMM-07251123) | Inquiry | |
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These teto-Klf9 knock-in mice provide inducible and reversible overexpression of the transcription factor Klf9 (Kruppel-like factor 9) gene regulated by the tetracycline-responsive promoter (tetO). Silencing of KLF9 protein may be regulated with tetracycline or its analog doxycycline (dox) when combined with a strain expressing tetracycline-controlled transcriptional silencer protein (tTS or rtTS). These mice are a Tet tool strain - allowing dox-conditional expression of TRE promoter-driven target genes.
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For Research Use Only.