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B6;129S-Klf9tm1.1Sahay/J
Cat. No.: CEMM-07251123
Common Name: tetO-Klf9
These teto-Klf9 knock-in mice provide inducible and reversible overexpression of the transcription factor Klf9 (Kruppel-like factor 9) gene regulated by the tetracycline-responsive promoter (tetO). Silencing of KLF9 protein may be regulated with tetracycline or its analog doxycycline (dox) when combined with a strain expressing tetracycline-controlled transcriptional silencer protein (tTS or rtTS). These mice are a Tet tool strain - allowing dox-conditional expression of TRE promoter-driven target genes.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Klf9tm1.1Sahay
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Inducible
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| Gene Symbol |
Klf9
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| Gene Name |
Kruppel-like factor 9
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| Chromosome |
19
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| MGI Accession ID | show more close |
| Strain of Origin |
129S6/SvEvTac
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| Molecular Note |
A loxP site, FRT flanked pgk-neo construct, tetO construct and loxP site were inserted upstream of the translation initiation start site via homologous recombination. Flp mediated recombination removed the neo cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, heterozygous mice may be bred together, to wildtype (non-carrier) mice from the colony or to C57BL/6J inbred mice. Alternatively, the donating investigator reports that homozygous mice are viable, fertile, and may be bred together.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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