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STOCK En2tm4(cre/ERT2)Alj/J
Cat. No.: CEMM-07250087
En2-CreERT2 mutant mice harbor the Cre-ERT2 fusion gene under control of the endogenous engrailed 2 locus. When En2-CreERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in En2-expressing tissues (including the developing mesencephalon, rhombomere 1, and jaw muscles, as well as the embryonic and adult cerebellum).
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
En2tm4(cre/ERT2)Alj
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| Allele Name |
targeted mutation 4
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| Allele Attributes |
Recombinase-expressing; Inducible
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| Gene Symbol |
En2
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| Gene Name |
engrailed 2
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| Chromosome |
5
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| Expressed Genes |
cre/ERT2, Cre recombinase and estrogen receptor 1 (human) fusion gene
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| MGI Accession ID | show more close |
| Site of Expression |
Developing mesencephalon, rhombomere 1, and jaw muscles, as well as the embryonic and adult cerebellum (after induction).
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| Strain of Origin |
129S6/SvEvTac
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| Molecular Note |
A tamoxifen dependent form of Cre recombinase (CreER) and a loxP-flanked neo in reverse orientation were inserted into the 5' UTR. The neo was removed in vivo via Cre-mediated recombination.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
Wild-type from the colony
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| Breeding Considerations |
When maintaining a live colony, heterozygous mice may be bred together or with wildtype siblings. The donating investigator reports that homozygous mice are "semi-fertile" and do not breed well.
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For Research Use Only.
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