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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6.129(Cg)-Arctm1.1(cre/ERT2)Luo/J (Cat. No.: CEMM-07250465) | Inquiry | |
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The ArcCreER knock-in/knockout allele was designed to both abolish expression of the Arc immediate early gene and direct expression of the CreERT2 fusion protein from the Arc promoter/enhancer elements. These mice are a Cre-lox tool that allows inducible Cre expression in Arc-expressing cells/tissues; including neurons activated by specific somatosensory, visual, and auditory stimuli. Immediate early genes (IEGs) are the connection between gene expression and a neuron's electrical/synaptic activity (which defines the neuron's response properties).
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| STOCK Fostm2.1(icre/ERT2)Luo/J (Cat. No.: CEMM-07250793) | Inquiry | |
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Fos2A-iCreER knock-in (also called Fos2A-iCreERT2 or "TRAP2") was designed to have expression of a tamoxifen-inducible, improved Cre recombinase (icre/ERT2) from the Fos promoter/enhancer elements - without disrupting endogenous Fos expression. Fos2A-iCreER mice are a Cre-lox tool allowing inducible iCre recombination in Fos-expressing cells/tissues (including neurons activated by specific somatosensory, visual and auditory stimuli) or behavioral experiences such as enriched environment, fear conditioning or water deprivation. Immediate early genes (IEGs) are the connection between gene expression and a neuron's electrical/synaptic activity (which defines neuronal response properties).
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| B6;129S6-Gt(ROSA)26Sortm1(CAG-tdTomato*, -EGFP*)Ees/J (Cat. No.: CEMM-07250490) | Inquiry | |
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ROSAnT-nG mice are available on a congenic C57BL/6NJ background and the congenic version will replace this mixed background strain in the near future. ROSAnT-nG (also called nT/nG) is a nuclear-targeted, two-color fluorescent Cre reporter allele that express nuclear-localized red fluorescence in a widespread fashion prior to Cre recombinase exposure. Following exposure to Cre, nuclear-localized green fluorescence is observed. In addition to this B6;129 mixed genetic background ROSAnT-nG strain, the ROSAnT-nG reporter allele is also available on a C57BL/6NJ congenic background. The ROSAnT-nG reporter allele functions similarly to the mT/mG reporter allele (ROSAmT/mG), with nT/nG directed to nuclei and mT/mG directed to cell membrane.
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| STOCK En2tm6Alj/J (Cat. No.: CEMM-07250138) | Inquiry | |
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These En2lox mice have loxP sites flanking the engrailed homeodomain portion in exon 2 of the engrailed 2 gene. These mice may be used to generate conditional mutations for studying engrailed protein function in the developing mesencephalon, rhombomere 1, and jaw muscles, as well as the embryonic and adult cerebellum.
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| B6.129-Ntsr1tm1.1(cre)Giml/J (Cat. No.: CEMM-07250950) | Inquiry | |
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NtsR1ΔNeo-Cre mice have a Cre Recombinase sequence inserted downstream of the stop codon of the neurotensin receptor 1 (Ntsr1) gene. These mice may be useful as a reporter when studying developmental versus adult expression patterns of NtsR1.
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| B6.129-Ntsr2tm1.1(cre)Giml/J (Cat. No.: CEMM-07250952) | Inquiry | |
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NtsR2Cre mice have a Cre Recombinase sequence downstream of the stop codon of the neurotensin receptor 2 (Ntsr2) gene. These mice may be useful as a reporter when studying developmental versus adult expression patterns of NtsR2.
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| B6;129-Otx2tm2(cre/ERT2)Tlam/J (Cat. No.: CEMM-07250989) | Inquiry | |
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The knock-in/knock-out Otx2CreERT2 allele replaces exons 1 and 2 of the orthodenticle homeobox 2 (Otx2) with a tamoxifen-inducible Cre-ERT2 under direction of the endogenous Otx2 promoter. These Otx2CreERT2 mice may be useful in studying neural development, retinal development, cellular proliferation, and medulloblastoma.
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| STOCK Gbx2tm1.1(cre/ERT2)Jyhl/J (Cat. No.: CEMM-07250467) | Inquiry | |
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This strain expresses a CreERT2-IRES-EGFP cassette from the gastrulation brain homeobox 2 Gbx2 promoter/enhancer elements. These mice may be useful for lineage mapping of thalamic neuronal precursor cells.
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| B6;129S-Gt(ROSA)26Sortm66.1(CAG-tdTomato)Hze/J (Cat. No.: CEMM-07250462) | Inquiry | |
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Ai66(RCRL-tdT)Δneo mice (also called Ai66(RCRL-tdT)-D, Ai66Δneo, or Ai66D) harbor the Rosa-CAG-RoxSTOPRox-LoxSTOPLox-tdTomato::deltaNeo conditional allele designed with both a Rox-flanked STOP cassette and a loxP-flanked STOP cassette preventing transcription of the tdTomato fluorescent protein. After removal of the flanked STOP cassettes by Dre- and Cre-recombination, tdTomato fluorescence is expected in cells/tissues expressing both Dre recombinase and Cre recombinase.
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| B6.Cg-Snap25tm1.1Hze/J (Cat. No.: CEMM-07250464) | Inquiry | |
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The Snap25-LSL-2A-EGFP-D (also called Snap25-LSL-2A-EGFP-Δ or Snap25-LSL-2A-EGFP-Δneo/hygro) conditional allele is designed with a loxP-flanked STOP cassette and enhanced green fluorescent protein (EGFP) downstream of the synaptosomal-associated protein 25 (Snap25) translational STOP codon. Following Cre recombinase removal of the floxed STOP cassette, EGFP fluorescence is expected in cells/tissues where the expression patterns of Snap25 and Cre recombinase overlap. Snap25 is a t-SNARE protein. These mice may be useful as a Cre-lox tool for fluorescent visualization of synaptic vesicle/plasma membrane fusion.
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For Research Use Only.