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STOCK Gbx2tm1.1(cre/ERT2)Jyhl/J
Cat. No.: CEMM-07250467
Common Name: Gbx2CreER
This strain expresses a CreERT2-IRES-EGFP cassette from the gastrulation brain homeobox 2 Gbx2 promoter/enhancer elements. These mice may be useful for lineage mapping of thalamic neuronal precursor cells.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Gbx2tm1.1(cre/ERT2)Jyhl
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Recombinase-expressing; Inducible
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| Gene Symbol |
Gbx2
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| Gene Name |
gastrulation brain homeobox 2
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| Chromosome |
1
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| Expressed Genes |
cre/ERT2, Cre recombinase and estrogen receptor 1 (human) fusion gene
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| MGI Accession ID | show more close |
| Site of Expression |
When Gbx2 is induced EGFP immunofluorescence is observed in thalamic neuronal precursor cells in the diencephalon.
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| Strain of Origin |
Not Specified
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| Molecular Note |
A Cre/ERT2-IRES-EGFP-FRT flanked neo cassette was inserted into the 5' untranslated region via homologous recombination. The neo cassette was then removed by Flp mediated recombination. Expression patterns of Cre/ERT2 transcripts and EGFP proteins match those of the endogenous protein.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
Wild-type from the colony
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| Breeding Considerations |
When maintaining a live colony, heterozygous mice may be bred to wildtype mice from the colony. Homozygotes lack a cerebellum and thalamocortical projections, and die at birth.
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For Research Use Only.
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