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B6.129-Ntsr2tm1.1(cre)Giml/J
Cat. No.: CEMM-07250952
Common Name: NtsR2NEO-Cre
NtsR2Cre mice have a Cre Recombinase sequence downstream of the stop codon of the neurotensin receptor 2 (Ntsr2) gene. These mice may be useful as a reporter when studying developmental versus adult expression patterns of NtsR2.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Ntsr2tm1.1(cre)Giml
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Recombinase-expressing
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| Gene Symbol |
Ntsr2
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| Gene Name |
neurotensin receptor 2
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| Chromosome |
12
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| MGI Accession ID | show more close |
| Site of Expression |
Expressed throughout the central nervous system.
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| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
The targeting vector was generated by inserting an IRES-Cre between the stop codon and the polyadenylation site of the sequence encoding the 3' end of the mouse NtsR2 gene, with an FRT flanked NEO cassette placed upstream of the IRES-Cre. Correctly recombined ES clones via homologous recombination were expanded, and injected into mouse blastocystes to generate chimeric males. Mice were bred to a FlpO deleter line to remove neo cessette to make constitutive Cre expression throughout life.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, heterozygous mice may be bred to wildtype mice from the colony, or to C57BL/6J inbred mice. The donating investigator did not attempt to make a homozygous colony.
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| Breeding Strategy |
Wild-type x Heterozygote; Heterozygote x Wild-type
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For Research Use Only.
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