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B6.129-Ntsr1tm1.1(cre)Giml/J
Cat. No.: CEMM-07250950
Common Name: NtsR1ΔNEO-Cre
NtsR1ΔNeo-Cre mice have a Cre Recombinase sequence inserted downstream of the stop codon of the neurotensin receptor 1 (Ntsr1) gene. These mice may be useful as a reporter when studying developmental versus adult expression patterns of NtsR1.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Ntsr1tm1.1(cre)Giml
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Recombinase-expressing
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| Gene Symbol |
Ntsr1
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| Gene Name |
neurotensin receptor 1
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| Chromosome |
2
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| MGI Accession ID | show more close |
| Site of Expression |
Expressed in neurons in the ventral tegmental area of the brain and elsewhere, and is upregulated during gestation.
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| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
The targeting vector was generated by inserting an IRES-Cre between the stop codon and the polyadenylation site of the sequence encoding the 3' end of the mouse NtsR1 gene, with an FRT flanked NEO cassette placed upstream of the IRES-Cre. Correctly recombined ES clones via homologous recombination were expanded, and injected into mouse blastocystes to generate chimeric males. Mice were bred to a FlpO deleter line to remove neo cessette to make constitutive Cre expression throughout life.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, heterozygous mice may be bred to wildtype mice from the colony, or to C57BL/6J inbred mice. The donating investigator did not attempt to make a homozygous colony.
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For Research Use Only.
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