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B6;129-Otx2tm2(cre/ERT2)Tlam/J
Cat. No.: CEMM-07250989
Common Name: Otx2CreERT2
The knock-in/knock-out Otx2CreERT2 allele replaces exons 1 and 2 of the orthodenticle homeobox 2 (Otx2) with a tamoxifen-inducible Cre-ERT2 under direction of the endogenous Otx2 promoter. These Otx2CreERT2 mice may be useful in studying neural development, retinal development, cellular proliferation, and medulloblastoma.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Otx2tm2(cre/ERT2)Tlam
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| Allele Name |
targeted mutation 2
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| Allele Attributes |
Recombinase-expressing; Inducible
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| Gene Symbol |
Otx2
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| Gene Name |
orthodenticle homeobox 2
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| Chromosome |
14
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| MGI Accession ID | show more close |
| Strain of Origin |
129/Sv
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| Molecular Note |
A sequence encoding the tamoxifen-inducible Cre-ERT2 and a neomycin resistance gene replaced the coding region.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
129S1/SvImJ
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| Breeding Considerations |
When maintaining a live colony, heterozygous mice may be bred to wildtype mice from the colony. Homozygotes are embryonic lethal.
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| Breeding Strategy |
Wild-type x Heterozygote; Heterozygote x Wild-type
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For Research Use Only.
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