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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| STOCK Tg(Pmch-cre)1Lowl/J (Cat. No.: CEMM-07250286) | Inquiry | |
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These transgenic mice have the murine pro-melanin-concentrating hormone (Pmch or MCH) promoter/enhancer regions within the BAC transgene directing expression of Cre-recombinase. These mice may be useful for studying MCH-neuronal activities in controlling energy balance, glucose homeostasis, sleep, locomotion, and reward-related behaviors.
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| B6.Cg-Tg(Gfap-cre)77.6Mvs/J (Cat. No.: CEMM-07250246) | Inquiry | |
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| STOCK Tg(Nes-cre)1Wme/J (Cat. No.: CEMM-07250001) | Inquiry | |
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These bal1 mice express a transgene containing Cre recombinase under the control of the rat nestin promoter.
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| C57BL/6N-Tg(Ppp1r2-cre)4127Nkza/J (Cat. No.: CEMM-07250234) | Inquiry | |
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Hemizygous Ppp1r2-cre mice are viable and fertile, harboring a BAC transgene encoding a Cre-recombinase gene under the control of the protein phosphatase 1, regulatory (inhibitor) subunit 2 (Ppp1r2) gene. These mice may be useful for studying the development and pathophysiology of schizophrenia-related disorders.
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| FVB/N-Tg(CAG-EGFP, -ALPP)2.6Ggc/J (Cat. No.: CEMM-07250098) | Inquiry | |
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These piGAP transgenic reporter mice have expression of the eGFP-F-IRES-hPLAP dicistronic gene blocked by an upstream loxP-flanked STOP-polyA sequence. When bred to mice that express Cre recombinase, the resulting offspring will have the STOP-polyA sequence deleted in the cre-expressing tissue(s), permitting dicistronic expression of human Placental Alkaline Phosphatase (PLAP or ALPP) and farnesylated Enhanced Green Fluorescent Protein (eGFP-F; optimized to target expression to the cytoplasmic side of the plasma membrane). These piGAP transgenic reporter mice allow Cre-inducible, eGFP-F and hPLAP expression in multiple cell and tissue types.
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| STOCK Tg(Nefh-cre)12Kul/J (Cat. No.: CEMM-07250150) | Inquiry | |
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Mice harboring this mNF-H-cre transgene have nuclear localized-Cre recombinase expression directed primarily to cortex and hippocampus neurons coinciding the late stages of brain development by the mouse neurofilament-H gene promoter. These mice may be useful in generating conditional knockouts for neurobiological, neurodevelopmental, neuromuscular, amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease), or aging studies involving the neurons of the brain and spinal cord.
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| B6.FVB-Tg(CAG-EGFP, -Sumo1, -Sumo2, -Sumo3, -mCherry)10Weiy/J (Cat. No.: CEMM-07250885) | Inquiry | |
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CAG-SUMO line 10 mice have widespread EGFP fluorescence that can be replaced by SUMO1/2/3 paralog expression and mCherry fluorescence after Cre recombinase exposure. These mice may be useful for studying in vivo SUMO proteomics - for example, mechanistically linking SUMO conjugation (SUMOylation) and the SUMO-modified proteome to the pathological processes of human disorders.
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| B6N;129-Tg(CAG-CHRM3*, -mCitrine)1Ute/J (Cat. No.: CEMM-07250591) | Inquiry | |
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The CAG-LSL-Gq-DREADD allele (formerly called R26-LSL-Gq-DREADD) allows Cre recombinase-inducible expression of a CAG promoter-driven HA-hM3Dq-pta-mCitrine. Following cre-mediated removal of an upstream floxed-STOP cassette, expression of HA-tagged hM3Dq and mCitrine yellow fluorescent protein is observed. hM3Dq is a mutant G protein-coupled receptor (GPCR) that induces the canonical Gq pathway specifically following administration of the pharmacologically inert molecule clozapine-N-oxide (CNO). These CAG-LSL-Gq-DREADD mice may be useful for chemogenetic/pharmacogenetic studies to express an activating DREADD that effectively induces firing of neurons. Note on allele, transgene insertion and copy number: This was originally designed as a targeted insertion into the Gt(ROSA)26Sor locus.
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| FVB/NJ-Tg(Prnp-Tardbp, -EGFP)19Zxu/J (Cat. No.: CEMM-07250880) | Inquiry | |
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PrP-TDP43-IRES-EGFP line 19 transgenic mice (TDP-43 Tg19) have modest levels of TDP-43 overexpression in the central nervous system that results in diverse aspects of amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease). This modest/chronic elevation of TDP-43 may be useful for studying ALS and other neuromuscular conditions involving TDP-43 proteinopathy.
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| STOCK Tg(ACTB-tTA2, -MAPT/lacZ)1Luo/J (Cat. No.: CEMM-07250284) | Inquiry | |
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These CAG-stop-tTA2 transgenic mice have a loxP-flanked transcriptional STOP cassette preventing transcription of the downstream modified tetracycline-regulated transactivator (tTA2). Applying both Cre-lox and Tet-Off technologies, these CAG-stop-tTA2 transgenic mice may be useful to generate compound mutant mice in which expression of a tetracycline-responsive promoter element (TRE or tetO)-driven gene of interest can be both directed to the cell types defined by the chosen Cre recombinase expression, as well as turned off by the addition of tetracycline (or its analog doxycycline [dox]).
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For Research Use Only.