FVB/NJ-Tg(Prnp-Tardbp, -EGFP)19Zxu/J

Cat. No.: CEMM-07250880

Common Name: PrP-TDP43-IRES-EGFP line 19 (or Tg19)

PrP-TDP43-IRES-EGFP line 19 transgenic mice (TDP-43 Tg19) have modest levels of TDP-43 overexpression in the central nervous system that results in diverse aspects of amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease). This modest/chronic elevation of TDP-43 may be useful for studying ALS and other neuromuscular conditions involving TDP-43 proteinopathy.

Inquiry

Status	Live Mouse Frozen Embryo
Age	4 weeks 12 weeks Customized Age
Sex	Male Female

GENETICS
Allele Symbol	Tg(Prnp-Tardbp,-EGFP)19Zxu show more close
Allele Name	transgene insertion 19 show more close
Allele Attributes	Reporter; Inserted expressed sequence show more close
Gene Symbol	Tg(Prnp-Tardbp,-EGFP)19Zxu show more close
Gene Name	transgene insertion 19 show more close
Chromosome	UN show more close
MGI Accession ID	6469530 show more close
Strain of Origin	FVB/NJ show more close
Molecular Note	A loxP site, mouse Tardbp DNA binding protein cDNA sequence, an internal ribosome entry site (IRES), an enhanced green fluorescent protein sequence (EGFP), a second loxP site and polyA sequence was inserted between exon 2 and exon 3 of mouse Prnp gene. Founder line 19 was identified with GFP expression in central nervous system and desirable Tardbp expression level/pattern. show more close

HUSBANDRY
Suggested Controls	FVB/NJ Noncarrier show more close
Breeding Considerations	When maintaining a live colony, hemizygous mice may be bred together, to wildtype (non-carrier) mice from the colony or with FVB/NJ inbred mice. Alternatively, homozygous mice may be bred. show more close
Breeding Strategy	Hemizygote x Noncarrier; Noncarrier x Hemizygote show more close

For Research Use Only.