C57BL/6N-Tg(Ppp1r2-cre)4127Nkza/J

Cat. No.: CEMM-07250234

Hemizygous Ppp1r2-cre mice are viable and fertile, harboring a BAC transgene encoding a Cre-recombinase gene under the control of the protein phosphatase 1, regulatory (inhibitor) subunit 2 (Ppp1r2) gene. These mice may be useful for studying the development and pathophysiology of schizophrenia-related disorders.

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Status	Live Mouse Frozen Embryo
Age	4 weeks 12 weeks Customized Age
Sex	Male Female

GENETICS
Allele Symbol	Tg(Ppp1r2-cre)4127Nkza show more close
Allele Name	transgene insertion 4127 show more close
Allele Attributes	Recombinase-expressing show more close
Gene Symbol	Tg(Ppp1r2-cre)4127Nkza show more close
Gene Name	transgene insertion 4127 show more close
Chromosome	UN show more close
Expressed Genes	Cre, Cre recombinase, bacteriophage P1 show more close
MGI Accession ID	4421503 show more close
Site of Expression	When these mice are bred with mice containing loxP-flanked sequence, Cre-mediated recombination will result in deletion of the floxed sequences in the Cre-expressing GABAergic neurons of the offspring. show more close
Strain of Origin	C57BL/6N show more close
Molecular Note	BAC homologous recombination was used to insert Cre cDNA (fused with a nuclear localization signal (NLS) sequence) immediately upstream of the initiation codon of the Ppp1r2 gene in BAC RPCI-24-322B4. The Cre cDNA was followed by the bovin growth hormone-derived polyadenylation signal.In one clone, a 12-kb deletion introduced around the initial methionine codon of the apolipoprotein D (Apod) coding sequence, located 50 kb upstream of Ppp1r2, was identified. This clone was used to prevent overexpression of Apod in the brain of transgenic mice. show more close

HUSBANDRY
Suggested Controls	C57BL/6NJ Noncarrier show more close
Breeding Considerations	When maintaining a live colony, hemizygous mice may be bred to wildtype (non-carriers) from the colony, or to C57BL/6NJ. show more close

For Research Use Only.