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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
STOCK Tg(En2-cre)22Alj/J (Cat. No.: CEMM-07250137) | Inquiry | |
These En2-cre line 22 transgenic mice (also called En2cre-22, En2cre line Tg22, or En2-cre tg-22) have the mouse engrailed 2 (En2) promoter/enhancer elements directing expression of Cre recombinase to a subset of En2-expressing cells; including the embryonic midbrain-hindbrain (mesencephalon-metencephalon) constriction region of the developing brain that gives rise to the posterior midbrain and medial cerebellum.
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B6.FVB-Tg(Slc32a1-cre)2.1Hzo/FrkJ (Cat. No.: CEMM-07250354) | Inquiry | |
Mice hemizygous for the BAC Viaat-cre transgene are viable and fertile, with solute carrier family 32 (GABA vesicular transporter), member 1 (Slc32a1 or Viaat) promoter/enhancer regions driving expression of cre-recombinase. These mice may be useful for studying GABAergic neuronal function.
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STOCK Tg(Slc17a8-icre)1Edw/SealJ (Cat. No.: CEMM-07250395) | Inquiry | |
iCre recombinase expression is evident in interneurons of the brain and in amacrine cells of the inner retina.
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B6.Cg-Tg(Arc-cre/ERT2)MRhn/CdnyJ (Cat. No.: CEMM-07250469) | Inquiry | |
These mice express Cre-ERT2 under the direction of the activity regulated cytoskeletal-associated protein (Arc) promoter/enhancer regions. They are useful in comparing activation of neuronal populations in the hippocampus during encoding and retrieval of memory.
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C57BL/6-Tg(Pmch-cre)1Rck/J (Cat. No.: CEMM-07250521) | Inquiry | |
These Tg(Pmch-cre) mice have the pro-melanin-concentrating hormone promoter directing expression of a cre coding sequence in lateral hypothalamus melanin-concentrating hormone neurons.
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B6.Cg-Tg(CAG-GCaMP2)2Mik/J (Cat. No.: CEMM-07250570) | Inquiry | |
pCAGGS-GCaMP2 transgenic mice are a fluorescent calcium indicator strain that exhibits high calcium-sensor expression in widespread cells/tissues. Upon GCaMP2 binding to calcium, increased EGFP fluorescence is observed. The entire transgene is flanked with loxP sites.
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B6.Cg-Tg(CAG-GFP, -EIF4EBP1*)2969Als/J (Cat. No.: CEMM-07250754) | Inquiry | |
The Tg-4EBP1mt transgene has a floxed-GFP-3xSTOP cassette preventing expression of constitutively active, mTORC1-nonresponsive mutant variant of human EIF4EBP1. These mice may be useful for Cre recombinase-inducible studies involving mTOR complex 1 signaling and metabolism.
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B6.Cg-Tg(SOD1*G37R)1Dwc/J (Cat. No.: CEMM-07250304) | Inquiry | |
These LoxSOD1G37R mice harbor a floxed transgene comprised of the human SOD1 gene bearing a G37R mutation that is causative of inherited Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease). These mice develop ALS-like fatal, progressive paralysis by 1 year of age.
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B6N.FVB-Tg(Mpz-cre)26Mes/J (Cat. No.: CEMM-07250382) | Inquiry | |
These transgenic mice contain the myelin protein zero (P0) (Mpz) promoter driving expression of Cre recombinase in Schwann cells. These mice may be useful for studying the myelination of peripheral nerve cells.
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FVB/N-Tg(Mpz-cre)26Mes/J (Cat. No.: CEMM-07250383) | Inquiry | |
These transgenic mice contain the myelin protein zero (P0) (Mpz) promoter driving expression of Cre recombinase in Schwann cell. These mice may be useful for studying the myelination of peripheral nerve cells.
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